Lifestyle

Coffee consumption unrelated to alertness

July, 2010

A recent study indicates that the alertness benefits of caffeine may simply reflect the reversal of the fatiguing effects of caffeine withdrawal.

A study involving 379 individuals who abstained from caffeine for 16 hours has revealed little variance in levels of alertness after receiving caffeine. Those who were medium/high caffeine consumers reported a decrease in alertness and an increase in headache if given the placebo, neither of which were reported by those who received caffeine. However, their post-caffeine levels of alertness were no higher than the non/low consumers who received a placebo, suggesting caffeine only brings coffee drinkers back up to 'normal'. In other words, the stimulatory effects of caffeine appears to be an illusion generated by the reversal of the fatiguing effects of acute caffeine withdrawal.

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Animal studies indicate caffeine may slow dementia and cognitive decline but human studies less conclusive

July, 2010
  • Several recent studies and reviews suggest that the benefits of caffeine for age-related cognitive impairment and dementia are limited. It may be that the association only exists for women.

A special supplement in the Journal of Alzheimer's Disease focuses on the effects of caffeine on dementia and age-related cognitive decline. Here are the highlights:

A mouse study has found memory restoration and lower levels of amyloid-beta in Alzheimer’s mice following only 1-2 months of caffeine treatment. The researchers talk of “ a surprising ability of moderate caffeine intake to protect against or treat AD”, and define moderate intake as around 5 cups of coffee a day(!).

A review of studies into the relation between caffeine intake, diabetes, cognition and dementia, concludes that indications that coffee/caffeine consumption is associated with a decreased risk of Type 2 diabetes and possibly also with a decreased dementia risk, cannot yet be confirmed with any certainty.

A study involving 351 older adults without dementia found the association between caffeine intake and cognitive performance disappeared once socioeconomic status was taken into account.

A study involving 641 older adults found caffeine consumption was significantly associated with less cognitive decline for women only. Supporting this, white matter lesions were significantly fewer in women consuming more than 3 units of caffeine per day (after adjustment for age) than in women consuming less.

A Portuguese study involving 648 older adults found that caffeine intake was associated with a lower risk of cognitive decline in women, but not significantly in men.

A review of published studies examining the relation between caffeine intake and cognitive decline or dementia shows a trend towards a protective effect of caffeine, but because of the limited number of epidemiological studies, and the methodological differences between them, is unable to come up with a definitive conclusion.

A review of published epidemiological studies looking at the association between caffeine intake and Parkinson’s Disease confirms that higher caffeine intake is associated with a lower risk of developing Parkinson’s Disease (though this association may be stronger for men than women). Other studies provide evidence of caffeine’s potential in treatment, improving both the motor deficits and non-motor symptoms of Parkinson’s.

Reference: 

Arendash, G.W. & Cao, C. Caffeine and Coffee as Therapeutics Against Alzheimer’s Disease. Journal of Alzheimer's Disease, 20 (Supp 1), 117-126.
Biessels, G.J. Caffeine, Diabetes, Cognition, and Dementia. Journal of Alzheimer's Disease, 20 (Supp 1), 143-150.
Kyle, J., Fox, H.C. & Whalley, L.J. Caffeine, Cognition, and Socioeconomic Status. Journal of Alzheimer's Disease, 20 (Supp 1), 151-159.
Ritchie, K. et al. Caffeine, Cognitive Functioning, and White Matter Lesions in the Elderly: Establishing Causality from Epidemiological Evidence. Journal of Alzheimer's Disease, 20 (Supp 1), 161-161
Santos, C. et al. Caffeine Intake is Associated with a Lower Risk of Cognitive Decline: A Cohort Study from Portugal. Journal of Alzheimer's Disease, 20 (Supp 1), 175-185.
Santos, C. et al. Caffeine Intake and Dementia: Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease, 20 (Supp 1), 187-204.
Costa, J. et al. Caffeine Exposure and the Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis of Observational Studies. Journal of Alzheimer's Disease, 20 (Supp 1), 221-238.
Prediger, R.D.S. Effects of Caffeine in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Non-Motor Symptoms. Journal of Alzheimer's Disease, 20 (Supp 1), 205-220.

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Extending lifespan has mixed effects on learning and memory

July, 2010

Although roundworm research suggesting different effects at different ages is concerned with genetic manipulation, we may speculate that restricting your food intake is a bad idea for young adults but good for the old, while reducing sugar may be better for the young than it is for the old.

Studies on the roundworm C. elegans have revealed that the molecules required for learning and memory are the same from C. elegans to mammals, suggesting that the basic mechanisms underlying learning and memory are ancient, and that this animal can serve as a testing ground for treatments for age-related memory loss. Intriguingly, a comparison of two known regulators of longevity — reducing calorie intake and reducing activity in the insulin-signaling pathway (achieved through genetic manipulation) — has found that these two treatments produce very different effects on memory. While dietary restriction impaired memory in early adulthood, it maintained memory with age. On the other hand, reduced insulin signaling improved early adult memory performance but failed to preserve it with age. These different effects appear to be linked to expression of CREB, a protein known to be important for long-term memory. Young roundworms with defective insulin receptors had higher levels of CREB protein, while those worms genetically altered to eat less had low levels, but the level did not diminish with age. These findings add to our understanding of why memory declines with age.

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Anorexia affects brain volume

July, 2010

Anorexic women when starved showed smaller brains, but happily this appears to be reversible.

A study comparing the brains 32 adult women with Anorexia Nervosa and 21 healthy women has revealed that when the women with anorexia were in a state of starvation they had less brain tissue (especially in grey matter) compared to the healthy women. Those who had the illness the longest had the greatest reductions in brain volume when underweight. Happily, these deficits began to reverse after several weeks of weight gain.

Reference: 

[1588] Roberto, C. A., Mayer L. E. S., Brickman A. M., Barnes A., Muraskin J., Yeung L-K., et al.
(2010).  Brain tissue volume changes following weight gain in adults with anorexia nervosa.
International Journal of Eating Disorders. 9999(9999), NA - NA.

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Link between cigarette smoking and IQ

March, 2010

Data from more than 20,000 18-year-old Israeli men has revealed that IQ scores are lower in male adolescents who smoke compared to non-smokers, and lower still in those who smoked more than a pack a day.

Data from more than 20,000 18-year-old Israeli men has revealed that IQ scores are lower in male adolescents who smoke compared to non-smokers, and in twin brothers who smoke compared to their non-smoking brothers. The average IQ for a non-smoker was about 101, while the smokers' average was about 94, with those who smoked more than a pack a day being lower still, at about 90. 28% of the sample smoked one or more cigarettes a day, 3% identified as ex-smokers, and 68% said they never smoked.

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Moderate drinking before trauma leads to more flashbacks

March, 2010

A study has found that those given alcohol equivalent to around 2 glasses of wine experienced more flashbacks from a video of serious road traffic accidents than those given twice as much alcohol, and those given none. The findings support the view that flashbacks reflect the reactivation of sensory memory in the absence of contextual memory.

A study in which nearly 50 participants consumed either alcohol (.4 or .8 g/kg, around 2 or 4 glasses of wine) or a placebo drink, performed a memory task, then were shown a video of serious road traffic accidents, has found that those given the smaller amount of alcohol experienced more flashbacks during the next week than those given the larger amount of alcohol, and those given no alcohol. Although that may seem to suggest drinking a large amount of alcohol might result in less involuntary re-experiencing of the event, excessive alcohol produced an overall reduction in memory which may be even more distressing if they then imagine a 'worse case scenario.' The findings support the view that flashbacks reflect the reactivation of image-based egocentric representations (based on sensory features) in the absence of a corresponding allocentric representing (incorporating the spatiotemporal context). Alcohol appears to impair allocentric (contextual) memory first.

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Everyone looks the same when you drink

March, 2010

It’s well established that we are better at recognizing faces of our own racial group, but a new study shows that this ability disappears when we’re mildly intoxicated.

It’s well established that we are better at recognizing faces of our own racial group, but a new study shows that this ability disappears when we’re mildly intoxicated. The study tested about 140 university students of Western European and east-Asian descent and found that recognition of different-race faces was unaffected by alcohol, yet both groups showed impaired recognition of own-race faces, bringing it down to about the same level of accuracy as for different-race faces. Those given a placebo drink were unaffected.

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Fish oil supplements provide no benefit to brain power

April, 2010

The largest ever trial of fish oil supplements has found no evidence that they offer benefits for cognitive function in older people. However, neither the trial group or the placebo group showed any cognitive decline over the two-year period of the study.

The largest ever trial of fish oil supplements has found no evidence that they offer benefits for cognitive function in older people. The British study enrolled 867 participants aged 70-80 years, and lasted two years. After two years, those receiving fish oil capsules had significantly higher levels of omega-3 fatty acids in their blood than those receiving placebo capsules. However, cognitive function did not decline in either group over the period. The researchers caution that it may be that more time is needed for benefits to show.

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Time of day effects in immediate and delayed memory

Journal Article: 

Folkard, S. & Monk, T.H. (1978). Time of day effects in immediate and delayed memory. In M. M. Gruneberg, P. E. Morris & R.N. Sykes (eds.). Practical aspects of memory. London: Academic Press.

  • The time of day doesn't appear to significantly affect your ability to remember (retrieve information).
  • Time of day does appear to affect your ability to make good memory codes (learn).

In other words, what's important is the time of day you hear/see/read something, not when you try and remember it.

  • information learned in the morning shows better immediate retention, but worse long-term retention
  • short-term memory appears to improve as arousal levels fall

Three experiments investigated whether the time of day had an effect on short-term or long-term memory.

In the first experiment, the material used was a factual article from a New Scientist magazine. Short-term memory (as measured by 10 multi-choice questions) was best if the article had been read at 8am, and lowest if it had been read at 8pm. Surprisingly, there was a slight, short-lived improvement after lunch (during the post-lunch dip in arousal level), and another one after 8pm (at a similar dip in arousal). Long-term memory (as measured by performance on a category instance task) was apparently not affected by time of day. Nor was reading speed.

In the second experiment, the subjects listened to a story, at either 9am or 3pm. Their recall was tested immediately and again a week later. It was found that short-term recall was better if the story was heard at 9am but long-term recall was better if it had been heard at 3pm. It didn't seem to matter whether testing occurred at 9am or 3pm, nor did it matter whether the test occurred at the same time of day as the story was heard.

In the third experiment, the subjects were shift workers. The subjects, who were nurses, were shown a ten minute film on the use of radium therapy. The times used were more extreme this time: 8.30pm and 4am. Long-term recall was tested at four weeks. Long-term recall was consistently better if the film had been seen at 8.30pm than if it had been seen at 4am, but there was no effect on immediate recall. However, in the group least adjusted to shift work (part-time nurses and those on their first night shift), short-term recall was better if the film had been seen at 4am, while among the most adjusted group the reverse was true (short-term recall was best if the film had been seen at 8.30pm). Again, the time of testing made no difference.

Overall then, the experiments found that the time at which the information was presented consistently influenced immediate and delayed retention in opposite directions. It is not clear why there should be a differential effect. There was no evidence that retrieval efficiency was affected by the time of day.

An interesting implication of this work is that the recommendation from studies early this century, that academic work is better taught in the morning and physical subjects in the afternoon (based on findings that immediate memory was better in mid-morning, and perceptual-motor activity in the afternoon), may have been ill-founded.

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Low vitamin D levels associated with poorer cognition in older men

April, 2008

A study of over 3,100 older men (49-71) from across Europe has found that men with higher levels of vitamin D performed consistently better in an attention and speed of processing task. There was no difference on visual memory tasks. Although previous studies have suggested low vitamin D levels may be associated with poorer cognitive performance, findings have been inconsistent. Vitamin D is primarily synthesised from sun exposure but is also found in certain foods such as oily fish.

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