Lifestyle

Role of expectation on memory consolidation during sleep

March, 2011

A new study suggests sleep’s benefits for memory consolidation depend on you wanting to remember.

Two experiments involving a total of 191 volunteers have investigated the parameters of sleep’s effect on learning. In the first experiment, people learned 40 pairs of words, while in the second experiment, subjects played a card game matching pictures of animals and objects, and also practiced sequences of finger taps. In both groups, half the volunteers were told immediately following the tasks that they would be tested in 10 hours. Some of the participants slept during this time.

As expected, those that slept performed better on the tests (all of them: word recall, visuospatial, and procedural motor memory), but the really interesting bit is that it turned out it was only the people who slept who also knew a test was coming that had improved memory recall. These people showed greater brain activity during deep or "slow wave" sleep, and for these people only, the greater the activity during slow-wave sleep, the better their recall.

Those who didn’t sleep, however, were unaffected by whether they knew there would be a test or not.

Of course, this doesn’t mean you never remember things you don’t intend or want to remember! There is more than one process going on in the encoding and storing of our memories. However, it does confirm the importance of intention, and cast light perhaps on some of your learning failures.

Reference: 

[2148] Wilhelm, I., Diekelmann S., Molzow I., Ayoub A., Mölle M., & Born J.
(2011).  Sleep Selectively Enhances Memory Expected to Be of Future Relevance.
The Journal of Neuroscience. 31(5), 1563 - 1569.

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Metabolic syndrome linked to memory loss in older people

March, 2011

Three more studies point to the increased risk of memory loss in older adults with cardiovascular problems.

The new label of ‘metabolic syndrome’ applies to those having three or more of the following risk factors: high blood pressure, excess belly fat, higher than normal triglycerides, high blood sugar and low high-density lipoprotein (HDL) cholesterol (the "good" cholesterol). Metabolic syndrome has been linked to increased risk of heart attack.

A new French study, involving over 7,000 older adults (65+) has found that those with metabolic syndrome were 20% more likely to show cognitive decline on a memory test (MMSE) over a two or four year interval. They were also 13% more likely to show cognitive decline on a visual working memory test. Specifically, higher triglycerides and low HDL cholesterol were linked to poorer memory scores; diabetes (but not higher fasting blood sugar) was linked to poorer visual working memory and word fluency scores.

The findings point to the importance of managing the symptoms of metabolic syndrome.

High cholesterol and blood pressure in middle age tied to early memory problems

Another study, involving some 4800 middle-aged adults (average age 55), has found that those with higher cardiovascular risk were more likely to have lower cognitive function and a faster rate of cognitive decline over a 10-year period. A 10% higher cardiovascular risk was associated not only with increased rate of overall mental decline, but also poorer cognitive test scores in all areas except reasoning for men and fluency for women.

The cardiovascular risk score is based on age, sex, HDL cholesterol, total cholesterol, systolic blood pressure and whether participants smoked or had diabetes.

Memory problems may be sign of stroke risk

A very large study (part of the REGARDS study) tested people age 45 and older (average age 67) who had never had a stroke. Some 14,842 people took a verbal fluency test, and 17,851 people took a word recall memory test. In the next 4.5 years, 123 participants who had taken the verbal fluency test and 129 participants who had taken the memory test experienced a stroke.

Those who had scored in the bottom 20% for verbal fluency were 3.6 times more likely to develop a stroke than those who scored in the top 20%. For the memory test, those who scored in the bottom 20% were 3.5 times more likely to have a stroke than those in the top quintile.

The effect was greatest at the younger ages. At age 50, those who scored in the bottom quintile of the memory test were 9.4 times more likely to later have a stroke than those in the top quintile.

 

Together, these studies, which are consistent with many previous studies, confirm that cardiovascular problems and diabetes add to the risk of greater cognitive decline (and possible dementia) in old age. And point to the importance of treating these problems as soon as they appear.

Reference: 

[2147] Raffaitin, C., Féart C., Le Goff M., Amieva H., Helmer C., Akbaraly T. N., et al.
(2011).  Metabolic syndrome and cognitive decline in French elders.
Neurology. 76(6), 518 - 525.

The findings of the second and third studies are to be presented at the American Academy of Neurology's 63rd Annual Meeting in Honolulu April 9 to April 16, 2011

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Walking counteracts brain atrophy in older adults

February, 2011
  • Walking 40 minutes a day three days a week prevented ‘normal’ atrophy in the brains of older adults.

Another study has come out proclaiming the cognitive benefits of walking for older adults. Previously sedentary adults aged 55-80 who walked around a track for 40 minutes on three days a week for a year increased the size of their hippocampus, as well as their level of BDNF. Those assigned to a stretching routine showed no such growth. There were 120 participants in the study.

The growth of around 2% contrasts with the average loss of 1.4% hippocampal tissue in the stretching group — an amount of atrophy considered “normal” with age. Although both groups improved their performance on a computerized spatial memory test, the walkers improved more.

The findings are consistent with a number of animal studies showing aerobic exercise increases neurogenesis and BDNF in the hippocampus, and human studies pointing to a lower risk of cognitive decline and dementia in those who walk regularly.

Reference: 

[2097] Erickson, K. I., Voss M. W., Prakash R S., Basak C., Szabo A., Chaddock L., et al.
(Submitted).  Exercise training increases size of hippocampus and improves memory.
Proceedings of the National Academy of Sciences.

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What children eat for breakfast affects brain development

January, 2011

A Japanese study finds higher IQ among children who habitually eat white rice for breakfast, compared to those who eat white bread.

A number of studies have provided evidence that eating breakfast has an immediate benefit for cognitive performance in children. Now a new study suggests some “good” breakfasts are better than others.

A Japanese study of 290 healthy, well-nourished children, has revealed that those whose breakfast staple was white rice had a significantly larger ratio of gray matter in their brains, and several significantly larger regions, including the left superior temporal gyrus and bilateral caudate. Those who habitually ate white bread had significantly larger regional gray and white matter volumes of several regions, including the orbitofrontal gyri, right precentral gyrus and postcentral gyrus. Overall IQ scores, and scores on the perceptual organization subcomponent in particular, were significantly higher for the rice group.

One possible reason for the difference may be the difference in the glycemic index (GI) of these two substances; foods with a low GI are associated with less blood-glucose fluctuation than are those with a high GI. There is also a difference in fat content, with those eating white bread typically consuming more fat than those eating a rice-based breakfast. High levels of fat have been shown to reduce the expression of BDNF.

Regardless of the reason for the difference, the fact that breakfast staple type affects brain size and cognitive function in healthy children points to the importance of good nutrition during the years of brain development.

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Effects of caffeine vary with quantity and gender

January, 2011

Two recent studies suggest that caffeine is most effective in boosting your energy and alertness in small doses, and more effective for males.

A study involving 80 college students (34 men and 46 women) between the ages of 18 and 40, has found that those given a caffeinated energy drink reported feeling more stimulated and less tired than those given a decaffeinated soda or no drink. However, although reaction times were faster for those consuming caffeine than those given a placebo drink or no drink, reaction times slowed for increasing doses of caffeine, suggesting that smaller amounts of caffeine are more effective.

The three caffeine groups were given caffeine levels of either 1.8 ml/kg, 3.6 ml/kg or 5.4 ml/kg. The computerized "go/no-go" test which tested their reaction times was given half an hour after consuming the drinks.

In another study, 52 children aged 12-17 drank flattened Sprite containing caffeine at four concentrations: 0, 50 mg, 100 mg or 200 mg. Changes in blood pressure and heart rate were then checked every 10 minutes for one hour, at which point they were given a questionnaire and an opportunity to eat all they wanted of certain types of junk food.

Interestingly, there were significant gender differences, with boys drinking high-caffeine Sprite showing greater increases in diastolic blood pressure (the lower number) than boys drinking the low-caffeine Sprite, but girls being unaffected. Boys were also more inclined to report consuming caffeine for energy or “the rush”, than girls were.

Those participants who ingested the most caffeine also ate more high-sugar snack foods in the laboratory, and reported higher protein and fat consumption outside the lab.

Reference: 

[2047] Howard, M. A., & Marczinski C. A.
(2010).  Acute Effects of a Glucose Energy Drink on Behavioral Control.
Experimental and Clinical Psychopharmacology. 18(6), 553 - 561.

[2074] Temple, J. L., Dewey A. M., & Briatico L. N.
(2010).  Effects of Acute Caffeine Administration on Adolescents.
Experimental and Clinical Psychopharmacology. 18(6), 510 - 520.

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Benefits and dangers of iron

January, 2011

A study and a recent review suggest that while iron is important for brain health and development, whether it’s beneficial or harmful depends on the other nutrients consumed with it.

A study involving 676 children (7-9) in rural Nepal has found that those whose mothers received iron, folic acid and vitamin A supplementation during their pregnancies and for three months after the birth performed better on some measures of intellectual and motor functioning compared to offspring of mothers who received vitamin A alone. However, there was no significant benefit for those whose mothers received iron, folic acid and zinc (plus vitamin A), or multiple micronutrients.

A negative effect of adding zinc is consistent with other research indicating that zinc inhibits iron absorption. Interestingly, new “ground-breaking” research demonstrates further the complexity of iron’s effects on the body. The researcher argues that many neurodegenerative diseases (such as Alzheimer’s) are partly caused by poorly bound iron, and it is vital to consume nutrients which bind iron and prevent the production of the toxins it will otherwise produce.

Such nutrients include brightly-colored fruits (especially purple) and vegetables, and green tea.

It’s also argued that Vitamin C is only beneficial if iron is safely bound, and if it’s not, excess Vitamin C might be harmful.

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Beet juice promotes brain health in older adults

December, 2010

A small study suggests beet juice may improve blood flow in important regions of the brain in older adults.

Following on from previous studies showing that drinking beet juice can lower blood pressure, a study involving 14 older adults (average age 75) has found that after two days of eating a high-nitrate breakfast, which included 16 ounces of beet juice, blood flow to the white matter of the frontal lobes (especially between the dorsolateral prefrontal cortex and anterior cingulate cortex) had increased. This area is critical for executive functioning.

Poor blood flow in the brain is thought to be a factor in age-related cognitive decline and dementia.

High concentrations of nitrates are found in beets, as well as in celery, cabbage and other leafy green vegetables like spinach and some lettuce. When you eat high-nitrate foods, good bacteria in the mouth turn nitrate into nitrite. Research has found that nitrites can help open up the blood vessels in the body, increasing blood flow and oxygen specifically to places that are lacking oxygen.

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Chronic jet lag has long-lasting effects on cognition

December, 2010

A hamster study indicates that chronic jet lag changes the brain in ways that cause long-lasting memory and learning problems.

Twice a week for four weeks, female hamsters were subjected to six-hour time shifts equivalent to a New York-to-Paris airplane flight. Cognitive tests taken during the last two weeks of jet lag and a month after recovery from it revealed difficulty learning simple tasks that control hamsters achieved easily. Furthermore, the jet-lagged hamsters had only half the number of new neurons in the hippocampus that the control hamsters had.

The findings support earlier research indicating that chronic jet lag impairs memory and learning and reduces the size of the temporal lobe, and points to the loss of brain tissue as being due to reduced neurogenesis in the hippocampus. Although further research is needed to clarify this, indications are that the problem is not so much fewer neurons being created, but fewer new cells maturing into working cells, or perhaps new cells dying prematurely.

Hamsters are excellent subjects for circadian rhythm research because their rhythms are so precise.

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Does early retirement dull your brain?

November, 2010

A very large cross-country comparison of U.S. and European countries reveals a correlation between lower average scores on a simple memory test and higher rates of retirement among 60-64 year olds.

Do retired people tend to perform more poorly on cognitive tests than working people because you’re more likely to retire if your mental skills are starting to decline, or because retirement dulls the brain?

For nearly 20 years the United States has surveyed more than 22,000 Americans over age 50 every two years, and administered memory tests. A similar survey has also been taking place in Europe. A comparison of the 2004 data for the U.S., England, and eleven European countries (Austria, Belgium, Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden, and Switzerland) has now revealed differences in the level of cognitive performance among older adults between the countries (the 60-64 year age group was used as it represents the greatest retirement-age difference between nations).

These differences show some correlation with differences in the age of retirement. Moreover, the differences also correlate to differences in government policy in terms of pensions — supporting the view that it is retirement that is causing the mental decline, not the decline that brings about early retirement.

Memory was tested through a simple word recall task — recalling a list of 10 nouns immediately and 10 minutes later. People in the United States did best, with an average score of 11 out of a possible 20. Those in England were very close behind, and Denmark and Sweden were both around 10. Switzerland, Germany and the Netherlands, and Austria were all clustered between 9 and 9 ½; Belgium and Greece a little lower. France averaged 8; Italy 7; Spain (the lowest) just over 6.

Now when the average cognitive score is mapped against the percentage of retired for 60-64 year olds, the points for each country (with one exception) cluster around a line with a slope of -5, indicating that there is a systematic relationship between these two variables, and that on average being retired is associated with a lower memory score of about 5 points on a 20-point scale. This is a very large effect.

But the correlation is not (unsurprisingly) exact. Although the top scorers, U.S., England and Denmark, are among those nations who have lower retirement rates at this age, Switzerland has the same levels as the U.S., and Sweden has the fewest retired of all (around 40% compared to around 47% for the U.S. and Switzerland). Most interesting of all, why does Spain, which has around 74% retired, show such a low cognitive score, when five other countries have even higher rates of retirement (Austria has over 90% retired)?

There are of course many other differences between the countries. One obvious one to look at would be the degree to which older people who are not working for pay are involved in voluntary work. There’s also the question of the extent to which different countries might have different occupation profiles, assuming that some occupations are more mentally stimulating than others, and the degree to which retired people are engaged in other activities, such as hobbies and clubs.

The paper also raises an important point, namely, that retirement may be preceded by years of ‘winding-down’, during which workers become progressively more reluctant to keep up with changes in their field, and employers become increasingly reluctant to invest in their training.

Reference: 

[1932] Rohwedder, S., & Willis R. J.
(2010).  Mental Retirement.
Journal of Economic Perspectives. 24(1), 119 - 138.

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Walk for your brain’s sake

November, 2010

Walking helps older adults fight brain shrinkage, which is in turn associated with a reduced risk of cognitive impairment and dementia.

A long-running study involving 299 older adults (average age 78) has found that those who walked at least 72 blocks during a week of recorded activity (around six to nine miles) had greater gray matter volume nine years later. Gray matter does shrink as we get older, so this is not about growth so much as counteracting decline. Walking more than 72 blocks didn’t appear to confer any additional benefit (in terms of gray matter volume). Moreover, when assessed four years after that, those who had shown this increased brain size were only half as likely to have developed dementia (40% of the participants had developed dementia by this point).

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