Lifestyle

Blueberry juice & purple grape juice improve memory in older adults

January, 2010

Two small studies provide the first human evidence that blueberries and Concord grape juice can improve verbal memory in those with mild cognitive impairment.

A number of rodent studies have shown that blueberries can improve aging memory; now for the first time, a human study provides evidence. In the small study, nine older adults (mean age 76) with mild cognitive impairment (MCI) drank the equivalent of 2-2 l/2 cups of a commercially available blueberry juice every day. After three months they showed significantly improved paired associate learning and word list recall. The findings will of course have to be confirmed by larger trials, but they are consistent with other research.

A companion study involving 12 older adults (75-80) with MCI found that those who drank a pure variety of Concord grape juice for 12 weeks also saw their performance progressively improve on tests in which they had to learn lists and remember items placed in a certain order.

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Recreational drugs associated with deficits in planning memory

February, 2010

A small study has found that regular use ecstasy or cocaine is associated with impaired prospective memory (remembering things you plan to do).

A study involving 42 students who were ecstasy/polydrug users has found that ecstasy, or the regular use of several drugs, affects users' prospective memory (remembering things you plan to do), even when tests are controlled for cannabis, tobacco or alcohol use. Cocaine use in particular was prominently associated with prospective memory impairment. Deficits were evident in both lab-based and self-reported measurements.

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[164] Hadjiefthyvoulou, F., Fisk J. E., Montgomery C., & Bridges N. J.
(2010).  Everyday and prospective memory deficits in ecstasy/polydrug users.
J Psychopharmacol. 0269881109359101 - 0269881109359101.

Full text is available for a limited time at http://jop.sagepub.com/cgi/rapidpdf/0269881109359101v1

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Mediterranean diet may lower risk of brain damage

February, 2010

Seniors who were most closely following a Mediterranean-like diet were 36% less likely to have brain infarcts than those least following the diet.

Following on from studies showing that a Mediterranean-like diet may be associated with a lower risk of Alzheimer's disease and may lengthen survival in people with Alzheimer's, a six-year study of 712 New Yorkers has revealed that those who were most closely following a Mediterranean-like diet were 36% less likely to have brain infarcts (small areas of dead tissue linked to thinking problems), compared to those who were least following the diet. Those moderately following the diet were 21% less likely to have brain damage. The association was comparable to the effects of high blood pressure — that is, not eating a Mediterranean-like diet was like having high blood pressure. The Mediterranean diet includes high intake of vegetables, legumes, fruits, cereals, fish and monounsaturated fatty acids such as olive oil; low intake of saturated fatty acids, dairy products, meat and poultry; and mild to moderate amounts of alcohol.

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The study will be presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto April 10 to April 17, 2010.

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How lead exposure damages the brain

July, 2010

The damage lead exposure does to brains, especially young ones, is well-established, but new research tells us how it works.

We know that lead damages the brain, and that it does so by somehow affecting the release of neurotransmitters at synapses (the process by which neurons pass messages on). Now a new study explains exactly what lead does. Apparently, during the formation of synapses, lead lowers the levels of key proteins involved in neurotransmitter release (synaptophysin and synaptobrevin), and reduces the number of fast-releasing sites. These effects may occur through the inhibition of the NMDA receptor (which produced similar effects), disrupting the release of BDNF. While new synapses are created throughout our lives, there is an explosion of synapse formation during a child's early brain development, explaining why young children’s lead exposure is particularly damaging.

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CPAP therapy provides a memory boost for adults with sleep apnea

July, 2010

Patients with obstructive sleep apnea treated with CPAP therapy not only outperformed untreated OSA patients on a memory task, but they outperformed those without OSA.

A study involving 135 adults (33-65) has found that, not only did patients with obstructive sleep apnea who were being treated with CPAP therapy outperform untreated OSA patients on an overnight picture memory task, but they outperformed controls who did not have OSA. The memory task involved being shown 20 photographs before spending the night in the sleep lab, and then having to choose the familiar photo from 20 similar pairs in the morning. CPAP therapy provides a steady stream of air through a mask that is worn during sleep.

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Payne, J.D. et al. 2010. Regeneration of overnight memory consolidation ability in cpap patients. Presented at SLEEP 2010, the 24th annual meeting of the Associated Professional Sleep Societies LLC, in San Antonio, Texas.

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Sleep apnea in children and teens linked to lower academic grades

July, 2010

A study of overweight children and adolescents has found that moderate to severe obstructive sleep apnea was linked to both lower academic grades and behavioral concerns.

A study involving 163 overweight children and adolescents aged 10 to 17 has revealed that moderate to severe obstructive sleep apnea was linked to both lower academic grades and behavioral concerns. None of the students with moderate to severe OSA had an "A" average, and 30% had a "C" average or lower. In contrast, roughly 15% of those without sleep-disordered breathing had an "A" average, and only about 15% had a "C" average or lower. The results remained significant after adjustment for sex, race, socioeconomic status and sleep duration on school nights. OSA was particularly associated with inattention and poor study skills in real-world situations Forty-two students had moderate to severe OSA; 58 had mild OSA; 26 students were snorers; 37 had no sleep-disordered breathing.

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Beebe, D.W. et al. 2010. The association between sleep-disordered breathing, academic grades, and neurobehavioral functioning among overweight subjects during middle to late childhood. Presented at SLEEP 2010, the 24th annual meeting of the Associated Professional Sleep Societies LLC, in San Antonio, Texas.

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Sleep helps consolidation of a complex motor-learning task

July, 2010

Another study demonstrating the benefits of sleep for learning motor skills (in this case, a popular video game called "Guitar Hero III".

A number of studies have shown the benefits of sleep for consolidating motor learning. A new study extends this research to a more complex motor task: "Guitar Hero III", a popular video game. There was significantly greater improvement after a night’s sleep (average 68% in performance accuracy vs 63% for students who learnt the task in the morning and were tested in the evening), and a significant correlation between sleep duration and the amount of improvement.

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Higginson, C.D. et al. 2010. So you wanna be a rock star? Sleep on it. Presented at SLEEP 2010, the 24th annual meeting of the Associated Professional Sleep Societies LLC, in San Antonio, Texas.

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Regular bedtimes linked to better language, reading and math skills in preschool children

July, 2010

A large study reveals language and math skills were all better in 4-year-old children whose parents reported having rules about what time their child goes to bed.

A national study involving some 8,000 children, has revealed receptive and expressive language, phonological awareness, literacy and early math abilities were all better in 4-year-old children whose parents reported having rules about what time their child goes to bed. Having an earlier bedtime also was predictive of higher scores for most developmental measures. Recommendations are that preschool children get a minimum of 11 hours of sleep each night. These findings (which confirm earlier studies) indicate not only that lower scores on phonological awareness, literacy and early math skills are associated with getting less than this recommended amount of sleep, but that many children are not getting the recommended amount of sleep.

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Gaylor, E., Wei, X. & Burnham, M.M. 2010. Associations between nighttime sleep duration and developmental outcomes in a nationally representative sample of preschool-age children. Presented at SLEEP 2010, the 24th annual meeting of the Associated Professional Sleep Societies LLC, in San Antonio, Texas.

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Traffic noise disturbs sleep, affects morning performance

July, 2010

A sleep lab study has revealed that traffic noise during sleep produces significantly slower reaction times on a vigilance task in the morning.

It’s not just a matter of quantity; quality of sleep matters too. A study involving 72 adults (average age 40), whose sleep was monitored for 11 consecutive nights, has revealed that reaction times on a morning psychomotor vigilance task was significantly slower after exposure to recorded traffic noise during sleep. The slowing was directly related to the frequency and sound-pressure level of the nightly noise. Traffic noise has been identified as one cause of "environmental sleep disorder," which involves an environmental disturbance that causes a complaint of insomnia or daytime sleepiness. Other common causes include bright light and temperature extremes. The researchers also note that nighttime traffic noise may have even stronger effects on the performance of people who are more susceptible to sleep disturbances. Risk groups include children, shift workers, the elderly and people with chronic medical conditions. White noise, produced by fans, sound machines, and special applications for computers and smart phones, can be used to mask other noise.

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Elmenhorst, E. et al. 2010. Nocturnal traffic noise and morning cognitive performance. Presented at SLEEP 2010, the 24th annual meeting of the Associated Professional Sleep Societies LLC, in San Antonio, Texas.

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Teenage physical activity reduces risk of cognitive impairment later

July, 2010

A large long-running study reveals that physical activity is always important for women wanting to prevent cognitive impairment in old age, but being active in adolescence is most important.

A large longitudinal study, comparing physical activity at teenage, age 30, age 50, and late life against cognition of 9,344 women, has revealed that women who are physically active at any point have a lower risk of cognitive impairment in late-life compared to those who are inactive, but teenage physical activity is the most important. When age, education, marital status, diabetes, hypertension, depressive symptoms, smoking, and BMI were accounted for, only teenage physical activity status remained significantly associated with cognitive performance in old age. Although becoming active later in life didn’t make up for being inactive in adolescence, it did significantly reduce the risk of cognitive impairment compared to those who remained physically inactive. The findings are a strong argument for greater effort in increasing physical activity in today's youth.

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