Purpose in life protects against Alzheimer's disease

June, 2012

New results from a longitudinal study add to evidence that having a purpose and finding meaning in life protects against the harmful effects of Alzheimer’s pathology in the brain.

Here’s a different aspect to cognitive reserve. I have earlier reported on the first tranche of results from this study. Now new results, involving 246 older adults from the Rush Memory and Aging Project, have confirmed earlier findings that having a greater purpose in life may help protect against the brain damage wrought by Alzheimer’s disease.

Participants received an annual clinical evaluation for up to 10 years, which included detailed cognitive testing and neurological exams. They were also interviewed about their purpose in life, that is, the degree to which they derived meaning from life's experiences and were focused and intentional. After death (average age 88), their brains were examined for Alzheimer’s pathology.

Cognitive function, unsurprisingly, declined progressively with increased Alzheimer’s pathology (such as amyloid plaque and tau tangles). But ‘purpose in life’ modified this association, with higher levels of purposiveness reducing the effect of pathology on cognition. The effect was strongest for those with the greatest damage (especially tangles).

The analysis took into account depression, APOE gene status, and other relevant medical factors.

http://www.eurekalert.org/pub_releases/2012-05/rumc-pil050412.php

Reference:

[2954] Boyle, P. A., Buchman A. S., Wilson R. S., Yu L., Schneider J. A., & Bennett D. A.
(2012). Effect of Purpose in Life on the Relation Between Alzheimer Disease Pathologic Changes on Cognitive Function in Advanced Age.
Archives of General Psychiatry. 69(5), 499 - 504.

Quick takes

seniors

sense of purpose

Alzheimers

Related News

Dementia rate in extreme elderly population

Data from 330 participants in The 90+ Study, of whom 70% were women, has revealed an overall annual incidence rate of 18.2% for dementia, rising from 12.7% per year in the 90-94 age group, to 21.2% in the 95-99 age group and 40.7% per year in the 100+ age group.

Stress raises risk of mental decline in older diabetics

A study involving over 1000 older men and women (60-75) with type-2 diabetes has found that those with higher levels of the stress hormone cortisol in their blood are more likely to have experienced cognitive decline.

Mediterranean diet may lower risk of brain damage

Following on from studies showing that a Mediterranean-like diet may be associated with a lower risk of Alzheimer's disease and may lengthen survival in people with Alzheimer's, a six-year study of 712 New Yorkers has revealed that those who were most closely following a Mediterranean-like diet

New test to diagnose early stage Alzheimer's disease

A new test has been developed that measures amyloid-beta oligomers in the cerebrospinal fluid, promising a reliable means of early diagnosis.

New Alzheimer's test offers better opportunities for early detection

A computerized self test (CST) has been developed that is 96% accurate in diagnosing Alzheimer’s and

Major depression more than doubles risk of dementia among adults with diabetes

Both diabetes and clinical depression are known to be risk factors for dementia. Now a study that tracked nearly 4000 diabetics over 5 years has found having both increased the risk 2.7-fold.

Mother’s Alzheimer’s greater risk factor than father’s

A brain scanning study using Pittsburgh Compound B, involving 42 heal

Having greater purpose in life associated with reduced Alzheimer's risk

Data from over 900 community-dwelling older adults participating in the Rush Memory and Aging Project has found that greater purpose in life was associated with a substantially reduced risk of developing Alzheimer's disease, as well as a reduced risk of mild cognitive impairment and a slower rat

Factors predicting conversion of mild cognitive impairment to Alzheimer’s identified

An analysis technique using artificial neural networks has revealed that the most important factors for predicting whether amnestic mild cognitive impairment (

Untreated vision problems linked to dementia in the elderly

Data from 625 elderly Americans, followed for an average of 8.5 years, has revealed that those with very good or excellent vision at the beginning of the study had a 63% reduced risk of dementia over the study period.

Pages