Alzheimer's a much larger cause of death than reported

A new U.S. study suggests that Alzheimer's disease and other dementias are markedly under-reported on death certificates and medical records. Death certificates tend to only provide an immediate cause, such as pneumonia, and don’t mention the underlying condition that provoked it.

The study involved 2,566 older adults (65+; mean age 78) who received annual testing for dementia. The death rate was more than four times higher for those aged 75-84 who had been diagnosed with Alzheimer’s, and nearly three times higher in those with Alzheimer’s aged 85+. More than one-third of all deaths in those age groups were attributable to Alzheimer's disease. Median time from Alzheimer’s diagnosis to death was 3.8 years.

All this translates into an estimated mortality rate from Alzheimer's that is five to six times higher than the accepted number (derived from death certificates), which has put Alzheimer’s as the 6th leading cause of death.

http://www.eurekalert.org/pub_releases/2014-03/aaon-sad022614.php

[3579] James, B. D., Leurgans S. E., Hebert L. E., Scherr P. A., Yaffe K., & Bennett D. A.
(2014).  Contribution of Alzheimer disease to mortality in the United States.
Neurology. 82(12), 1045 - 1050.

Related News

A study involving mice lacking a master clock gene called Bmal1 has found that as the mice aged, their brains showed patterns of damage similar to those seen in Alzheimer's disease and other neurodegenerative disorders. Many of the injuries seemed to be caused by free radicals.

A new study involving 96 older adults initially free of dementia at the time of enrollment, of whom 12 subsequently developed mild Alzheimer’s, has clarified three fundamental issues about Alzheimer's: where it starts, why it starts there, and how it spreads.

Analysis of 5715 cases from the National Alzheimer's Coordinating Center (NACC) database has found that nearly 80% of more than 4600 Alzheimer's disease patients showed some degree of vascular pathology, compared with 67% of the controls, and 66% in the Parkinson's group.

The jugular venous reflux (JVR) occurs when the pressure gradient reverses the direction of blood flow in the veins, causing blood to leak backwards into the brain.

The

Following on from the evidence that Alzheimer’s brains show higher levels of metals such as iron, copper, and zinc, a mouse study has found that amyloid plaques in Alzheimer’s-like brains with significant neurodegeneration have about 25% more copper than those with little neurodegeneration.

An Italian study has found that a significant percentage of Alzheimer’s patients suffer from Obstructive Sleep Apnea Syndrome. This respiratory disorder, which causes people to temporarily stop breathing during their sleep, affects cerebral blood flow, promoting cognitive decline.

Data from 70 older adults (average age 76) in the Baltimore Longitudinal Study of Aging has found that those who reported poorer sleep (shorter sleep duration and lower sleep quality) showed a greater buildup of amyloid-beta plaques.

A new discovery helps explain why the “Alzheimer’s gene” ApoE4 is such a risk factor.

Analyses of cerebrospinal fluid from 15 patients with Alzheimer's disease, 20 patients with mild cognitive impairment, and 21 control subjects, plus brain tis

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news