Lifestyle

Cocoa & chocolate good for your cognition

A 2017 review of research has concluded that, although the number of studies into the cognitive effects of the cocoa bean is limited and has produced mixed results, on balance the evidence points to positive cognitive effects from regular intake of “cocoa flavanols”, as well as immediate benefits from consumption.

General cognition, attention, processing speed, and memory, have all shown benefits from regular consumption, particularly in those who are operating under some difficulty, such as older adults (and even more so for older adults with mild cognitive impairment). Immediate benefits occur particularly in demanding conditions, such as when you are fatigued or sleep deprived.

Cocoa flavanols have beneficial effects for cardiovascular health and can increase cerebral blood volume in the dentate gyrus of the hippocampus, an area particularly affected by aging.

Reference: 

Socci, V., Tempesta, D., Desideri, G., De Gennaro, L., & Ferrara, M. (2017). Enhancing Human Cognition with Cocoa Flavonoids. Frontiers in Nutrition, 4. https://doi.org/10.3389/fnut.2017.00019

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Leafy greens slow cognitive decline

Data from the long-running Rush Memory and Aging Project, involving 960 participants who completed a food frequency questionnaire from 2004 to 2013, found that those who ate one daily serving of green, leafy vegetables had a slower rate of cognitive decline than people who rarely or never ate them. Those who ate at least one serving of leafy green vegetables showed an equivalent of being 11 years younger cognitively.

Participants had an average age of 81 at the beginning of the study. Analysis took into account such factors as seafood and alcohol consumption, smoking, high blood pressure, obesity, education level and amount of physical and cognitive activities.

Reference: 

Martha Clare Morris, Yamin Wang, Lisa L. Barnes, David A. Bennett, Bess Dawson-Hughes, Sarah L. Booth. Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study. Neurology Jan 2018, 90 (3) e214-e222; DOI: 10.1212/WNL.0000000000004815

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High cholesterol intake & eggs don't increase dementia risk

A large, long-running Finnish study looking at the dietary habits of 2,497 men aged 42-60 has found that a high intake of dietary cholesterol was not associated with the risk of dementia or Alzheimer's disease, even among carriers of the ‘Alzheimer’s gene’ APOE4.

Previous research has found that the effect of dietary cholesterol on serum cholesterol levels is more visible in carriers of APOE4. In Finland, the prevalence of the APOE4 gene variant is exceptionally high and approximately a third of the population are carriers.

The consumption of eggs was not only not associated with an increased risk of dementia or Alzheimer's, but on the contrary, was associated with better cognitive performance on some tests.

The highest level of average daily dietary cholesterol intake was 520 mg and these participants consumed an average of one egg per day.

Reference: 

Ylilauri, M.P.T. et al. 2017. Association of dietary cholesterol and egg intakes with risk of incident dementia or Alzheimer's disease: The Kuopio Ischaemic Heart Disease Risk Factor Study. American Journal of Clinical Nutrition; First published online January 4, 2017. doi: 10.3945/ajcn.116.146753 http://ajcn.nutrition.org/content/early/2017/01/04/ajcn.116.146753.abstract?papetoc

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Fatty acids help the brain

A study involving 99 healthy older adults found that levels of monounsaturated fatty acids were associated with cognitive performance and the organization of the brain's attention network.

MUFAs are found in olive oils, nuts and avocados, and are a component of the Mediterranean diet, which has been associated with slower cognitive decline and lower dementia risk.

The study found that general intelligence was associated with how efficiently the dorsal attention network was functionally organized used a measure called small-world propensity, which describes how well the neural network is connected within locally clustered regions as well as across globally integrated systems.

In turn, they found that those with higher levels of MUFAs in their blood had greater small-world propensity in their dorsal attention network, suggesting that this is part of the reason for the link between diet and cognition.

And in another study by the same researchers, involving 94 older adults (65-75), blood levels of three omega-3 fatty acids (ALA, stearidonic acid and ecosatrienoic acid) were associated with levels of fluid intelligence, and this was mediated by the size of the left frontoparietal cortex. A larger left frontoparietal cortex was associated with higher levels of the omega-3 acids and better performance on tests of fluid intelligence.

A second study found that the size of a brain region called the fornix was associated with a balance of omega-3 and omega-6 fatty acids in the blood, and a more robust fornix was linked to better memory. The fornix is one of the first brain regions to be compromised in Alzheimer's disease.

Reference: 

Zamroziewicz, M. K., Talukdar, M. T., Zwilling, C. E., & Barbey, A. K. (2017). Nutritional status, brain network organization, and general intelligence. NeuroImage, 161, 241–250. https://doi.org/10.1016/j.neuroimage.2017.08.043

Zamroziewicz Marta K.,Paul Erick J.,Zwilling Chris E., et al. Predictors of Memory in Healthy Aging: Polyunsaturated Fatty Acid Balance and Fornix White Matter Integrity[J]. Aging and disease, 2017, 8(4): 372-383. http://www.aginganddisease.org/EN/10.14336/AD.2017.0501

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Stave off cognitive decline with seafood

Data from 915 older adults (mean age 81.4) participating in the very long-running Rush Memory and Aging Project, has found that those who reported eating seafood less than once a week showed greater cognitive decline compared to those who ate at least one seafood meal per week.

The food questionnaires included four types of seafood: tuna sandwiches; fish sticks, fish cakes and fish sandwiches; fresh fish as a main dish; and shrimp, lobster and crab. Those who ate at least one of those seafood meals per week ate an average of two seafood meals per week. Those and those who ate less than one of those seafood meals per week ate an average of 0.5 meals per week.

People who ate more seafood had better semantic memory and better perceptual speed (the ability to quickly compare letters, objects and patterns), but there wasn’t a significant difference in the rate of decline in episodic memory, working memory or visuospatial ability.

Factors such as education, physical activity, smoking and participating in mentally stimulating activities were taken into account in the analysis.

Interestingly, the protective association of seafood was stronger among those with the “Alzheimer’s gene” (APOE-ε4).

Reference: 

Ondine van de Rest, Yamin Wang, Lisa L. Barnes, Christine Tangney, David A. Bennett, Martha Clare Morris. APOEε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology May 2016, 86 (22) 2063-2070; DOI: 10.1212/WNL.0000000000002719

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Eating fish linked to better sleep and higher I.Q. for kids

A largish Chinese study, involving 541 9-11-year-olds, has found that those who ate fish at least once a week slept better and had higher IQ scores, on average, than those who ate fish less frequently or not at all.

The study suggests that sleep may be a reason for the association previous research has found between the consumption of fish / omega-3 oils and better cognition.

Children who reported eating fish weekly scored 4.8 points higher on the IQ tests than those who said they “seldom” or “never” consumed fish. Those whose meals sometimes included fish scored 3.3 points higher.

Reference: 

Liu, J., Cui, Y., Li, L., Wu, L., Hanlon, A., Pinto-Martin, J., Raine, A., & Hibbeln, J. R. (2017). The mediating role of sleep in the fish consumption – cognitive functioning relationship: A cohort study. Scientific Reports, 7(1), 17961. https://doi.org/10.1038/s41598-017-17520-w

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Lots of fruit & veges helps older brains

Data from the Canadian Longitudinal Study on Aging, involving 8,574 middle-aged and older adults (aged 45-85), has found that those who ate more vegetables and fruits and more nuts and pulses (such as lentils and beans) scored higher on tests of verbal fluency. Every increase in average daily fruit and vegetable intake was linked to higher verbal fluency scores, but the best outcomes were found among those who consumed at least 6 servings a day.

Additionally, those with stage 2 hypertension had lower verbal fluency scores, as did those with higher levels of body fat.

Reference: 

Fuller-Thomson, E., Saab, Z., Davison, K. M., Lin, S. L., Taler, V., Kobayashi, K., & Tong, H. (2020). Nutrition, Immigration and Health Determinants are Linked to Verbal Fluency among Anglophone Adults in the Canadian Longitudinal Study on Aging (CLSA). The Journal of Nutrition, Health & Aging, 24(6), 672–680. https://doi.org/10.1007/s12603-020-1402-8

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One meal high in saturated fat impairs our concentration

A study looking at how 51 women performed on a test of their attention after they ate either a meal high in saturated fat or the same meal made with sunflower oil (high in unsaturated fat), found their performance was worse after eating the high-saturated-fat meal than after they ate the meal containing a healthier fat.

This is particularly remarkable when you consider that both meals with high in fat, being designed to resemble fast-food meals that you might get at McDonald’s or Burger King. So this is showing that even this slight improvement can have a noticeable effect.

Additionally, those who had signs of leaky gut performed worse no matter which meal they had eaten.

Reference: 

Madison, A.A. et al. 2020. Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial, The American Journal of Clinical Nutrition, 111 (6), 1150–1158, https://doi.org/10.1093/ajcn/nqaa085

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Diet may help preserve cognitive function

Analysis of data from the Age-Related Eye Disease Study (AREDS) and AREDS2, involving a total of around 8,000 older adults, has found that those with the greatest adherence to the Mediterranean diet had the lowest risk of cognitive impairment. High fish and vegetable consumption appeared to have the greatest protective effect. At 10 years, AREDS2 participants with the highest fish consumption had the slowest rate of cognitive decline.

Those with the Alzheimer's gene ApoE4 on average had lower cognitive function scores and greater decline than those without the gene, but close adherence to a Mediterranean diet had similar benefits for people with and without the ApoE4 gene.

Reference: 

Keenan TD, Agron E, Mares J, Clemons TE, van Asten F, Swaroop A, and Chew E, for the AREDS and AREDS2 research groups. Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. April 14, 2020. Alzheimer's and Dementia.

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Western-style diet impairs brain function and increases desirability of sugary foods

A study involving 110 lean and healthy students (aged 20-23) found that those randomly assigned to a high energy western-style diet for a week performed worse on a memory test compared to those who ate their normal healthy diet. Moreover, those on the unhealthy diet then showed a greater tendency to eat more sugary foods.

The students at the beginning and end of the study were given breakfast in the lab. Before and after the meal, they completed word memory tests and scored a range of high-sugar breakfast foods according to how much they wanted and then liked the foods on eating them.

The more desirable people found the sugary food when full, following the western-style diet, the more impaired they were on the cognitive test. It’s suggested that both reflect impairment in hippocampal function.

Reference: 

Stevenson, R. J., Francis, H. M., Attuquayefio, T., Gupta, D., Yeomans, M. R., Oaten, M. J., & Davidson, T. (n.d.). Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet. Royal Society Open Science, 7(2), 191338. https://doi.org/10.1098/rsos.191338

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