New gene associated with increased risk of Alzheimer's

April, 2010

Another gene has been identified that appears to increase risk of Alzheimer’s. The gene is involved in influencing the body's levels of homocysteine (high levels are known to be a strong risk factor), and have also been implicated in coronary artery disease.

Another gene has been identified that appears to increase risk of Alzheimer’s. The gene, MTHFD1L, is located on chromosome six. Comparison of the genomes of 2,269 people with late-onset Alzheimer's disease and 3,107 people without the disease found those with a particular variation in this gene were almost twice as likely to develop Alzheimer's disease as those people without the variation. The gene is involved in influencing the body's levels of homocysteine (high levels are known to be a strong risk factor), and have also been implicated in coronary artery disease.

http://www.eurekalert.org/pub_releases/2010-04/aaon-nga033010.php

Reference:

The results were presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto, April 10–17, 2010.

homocysteine

seniors

risk factors

genes

Alzheimers

Related News

Intensive hypertension treatment reduces risk of cognitive impairment

A clinical trial involving 9361 older adults (50+) with hypertension but without diabetes or history of stroke has found that intensive control of blood pressure significantly reduced the risk of developing mild cognitive impairment.

Psychological distress a risk factor for dementia

Survey data from 6,807 Danish older adults (average age 60) in the Copenhagen City Heart Study, has found that being distressed in late midlife is associated with a higher risk of dementia in later life.

Poor sleep in older adults may increase Alzheimer’s risk

Poor sleep has been associated with Alzheimer's disease risk, but a new study suggests a specific aspect of sleep is important.

Lower tau levels may obscure early Alzheimer’s in black patients

Data from 1,215 older adults, of whom 173 (14%) were African-American, has found that, although brain scans showed no significant differences between black and white participants,

Older adults' distractability can be used to help put a face to a name

One important reason for the greater cognitive problems commonly experienced as we age, is our increasing difficulty in ignoring distracting and irrelevant information. But it may be that in some circumstances that propensity can be used to help memory.

Rigorous exercise does not slow dementia decline

A number of studies have found that physical exercise can help delay the onset of dementia, however the ability of exercise to slow the decline once dementia has set in is a more equivocal question. A large new study answers this question in the negative.

Gist memory may be why false memories are more common in older adults

Do older adults forget as much as they think, or is it rather that they ‘misremember’?

Lifestyle changes can prevent cognitive decline even in genetically at-risk individuals

A Finnish study involving over 1000 older adults suggests that a counselling program can prevent cognitive decline even among those with the Alzheimer’s gene.

The right diet may slow cognitive decline in stroke survivors

A pilot study involving 106 participants of the Rush Memory and Aging Project who had experienced a stroke followed participants for an average of 5.9 years, testing their cognitive function and monitoring their eating habits using food journals.

Reduced face memorization ability in those with MCI

A small Japanese study has found evidence that those with amnestic mild cognitive impairment (aMCI) show a specific decline in their ability to recognize faces, and this is accompanied by changes in the way they scan faces.

Pages