Green tea compound reverses Alzheimer's-like symptoms in mice

Compounds found in green tea and carrots reversed Alzheimer's-like symptoms in mice.

A diet containing compounds found in green tea and carrots reversed Alzheimer's-like symptoms in mice genetically programmed to develop the disease. The two compounds were EGCG (epigallocatechin-3-gallate), a key ingredient in green tea, and FA (ferulic acid), which is found in carrots, tomatoes, rice, wheat and oats.

After three months, the treatment completely restored working memory deficits seen in the Alzheimer's mice. The compounds appeared to help prevent amyloid precursor proteins from breaking up into amyloid beta, as well as reduce neuroinflammation and oxidative stress in the brain.

The amount of EGCG and FA was no more than could be gained from an appropriate diet.

https://www.eurekalert.org/pub_releases/2019-03/uosc-asr030619.php

Reference:

[4506] Mori, T., Koyama N., Tan J., Segawa T., Maeda M., & Town T.
(2019). Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
Journal of Biological Chemistry. 294(8), 2714 - 2731.

Diet

Alzheimers

Related News

Factors predicting conversion of mild cognitive impairment to Alzheimer’s identified

An analysis technique using artificial neural networks has revealed that the most important factors for predicting whether amnestic mild cognitive impairment (

Abdominal fat at middle age associated with greater risk of dementia

A study involving 733 participants from the Framingham Heart Study Offspring Cohort (average age 60) provides more evidence that excess abdominal fat places otherwise healthy, middle-aged people at greater risk for dementia later in life.

Obesity gene, carried by more than a third of the US population, leads to brain tissue loss

A variant of a gene called the fat mass and obesity associated (FTO) gene causes people to gain weight and puts them at risk for obesity. The gene variant is found in nearly half of all people in the U.S. with European ancestry, around one-quarter of U.S.

Fish oil supplements provide no benefit to brain power

The largest ever trial of fish oil supplements has found no evidence that they offer benefits for cognitive function in older people. The British study enrolled 867 participants aged 70-80 years, and lasted two years.

Pages