Brain blood flow deficits in Alzheimer's explained

  • Blood flow deficits in the brain, seen early on in Alzheimer's, have now been linked to some capilleries being block by white blood cells.

It’s been known that decreased blood flow in the brain occurs in people with Alzheimer's, and recent studies suggest that brain blood flow deficits are one of the earliest detectable symptoms of dementia. A study has now shown why it occurs: a small percentage of capillaries, the smallest blood vessels in the brain, are blocked by white blood cells stuck to the inside of the capillaries.

Recent research has shown that capilleries are vital for monitoring and directing blood flow around the brain.

https://www.eurekalert.org/pub_releases/2019-02/cu-rct021119.php

https://www.nature.com/articles/s41593-018-0329-4

Reference: 

[4458] Hernández, J. C. Cruz, Bracko O., Kersbergen C. J., Muse V., Haft-Javaherian M., Berg M., et al.
(2019).  Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models.
Nature Neuroscience. 22(3), 413 - 420.

Related News

Compound in celery, peppers reduces age-related memory deficits

Inflammation in the brain appears to be a key contributor to age-related memory problems, and it may be that this has to do with the dysregulation of

Low levels of omega-3 fatty acid may contribute to Alzheimer’s

Low levels of DHA, an omega-3 fatty acid, have been found in the brains of those with Alzheimer's disease, but the reason has not been known.
Cognitive decline is not simply a function of getting old

Findings from the long-running Religious Orders Study, from 354 Catholic nuns and priests who were given annual cognitive tests for up to 13 years before having their brains examined post-mortem, has revealed that even the very early cognitive impairments we regard as normal in aging are associa
Link among Alzheimer's disease, Down syndrome, atherosclerosis and diabetes

It’s been suggested before that Down syndrome and Alzheimer's are connected. Similarly, there has been evidence for connections between diabetes and Alzheimer’s, and cardiovascular disease and Alzheimer’s. Now new evidence shows that all of these share a common disease mechanism.
Alzheimer's memory problems originate with oligomers not plaques

While everyone agrees that amyloid-beta protein is part of the problem, not everyone agrees that amyloid plaques are the cause (or one of them) of Alzheimer’s. Other forms of amyloid-beta have been pointed to, including floating clumps called oligomers or ADDLs.

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news