Friends, family detect early Alzheimer's signs better than traditional tests

October, 2010

Cognitive tests only test you at a particular moment in time; early signs of Alzheimer's are more evident in declines in everyday behavior that are most visible to other people.

Confirming earlier research, a study involving 257 older adults (average age 75) has found that a two-minute questionnaire filled out by a close friend or family member is more accurate that standard cognitive tests in detecting early signs of Alzheimer’s.

The AD8 asks questions about changes in everyday activities:

Problems with judgment, such as bad financial decisions;
Reduced interest in hobbies and other activities;
Repeating of questions, stories or statements;
Trouble learning how to use a tool or appliance, such as a television remote control or a microwave;
Forgetting the month or year;
Difficulty handling complicated financial affairs, such as balancing a checkbook;
Difficulty remembering appointments; and
Consistent problems with thinking and memory.

Problems with two or more of these are grounds for further evaluation. The study found those with AD8 scores of 2 or more were very significantly more likely to have early biomarkers of Alzheimer’s (abnormal Pittsburgh compound B binding and cerebrospinal fluid biomarkers), and was better at detecting early stages of dementia than the MMSE. The AD8 has now been validated in several languages and is used in clinics around the world.

http://www.eurekalert.org/pub_releases/2010-09/wuso-ffd092710.php

Reference:

[1888] Galvin, J. E., Fagan A. M., Holtzman D. M., Mintun M. A., & Morris J. C.
(2010). Relationship of dementia screening tests with biomarkers of Alzheimer’s disease.
Brain. 133(11), 3290 - 3300.

seniors

Alzheimers

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