Physical activity saves hippocampus in people at risk of Alzheimer's

A study involving 97 healthy older adults (65-89) has found that those with the “Alzheimer’s gene” (APOe4) who didn’t engage in much physical activity showed a decrease in hippocampal volume (3%) over 18 months. Those with the gene who did exercise showed no change in the size of their hippocampus, nor did those without the gene, regardless of exercise. Physical activity was classified as low if the participant reported two or fewer days per week of low intensity activity, such as no activity, slow walking or light chores. Physical activity was classified as high if the participant reported three or more days/week of moderate to vigorous activity

The finding suggests that those with the risky gene will benefit most from regular exercise — indeed, this is as yet the only known means to counteract hippocampal shrinkage.

http://www.eurekalert.org/pub_releases/2014-04/uom-pak042214.php

[3605] Smith, J. Carson, Nielson K. A., Woodard J. L., Seidenberg M., Durgerian S., Hazlett K. E., et al.
(2014). Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease.
Frontiers in Aging Neuroscience. 6,

seniors

Exercise

hippocampus

Related News

How the Alzheimer’s gene increases risk

We know that the E4 variant of the APOE gene greatly increases the risk of developing Alzheimer’s disease, but the reason is a little more mysterious. It has been thought that it makes it easier for amyloid plaques to form because it produces a protein that binds to amyloid beta.

High blood sugar may raise Alzheimer’s risk

I’ve talked before about the evidence linking diabetes to an increased risk of Alzheimer’s disease, but now a new study suggests that elevated blood sugar levels increase Alzheimer’s risk even in those without diabetes, even in those without ‘pre-diabetes’.

Forgetfulness in old age may be related to changes in retrieval strategy

Evidence is accumulating that age-related cognitive decline is rooted in three related factors: processing speed slows down (because of

Gene doubles Alzheimer’s risk in African Americans

A study involving nearly 6,000 African American older adults has found those with a specific gene variant have almost double the risk of developing late-onset Alzheimer’s disease compared with African Americans who lack the variant.

Genetic test shows risk of cognitive impairment rather than Alzheimer’s

Analysis of data from 418 older adults (70+) has found that carriers of the ‘Alzheimer’s gene’, APOEe4, were 58% more likely to develop mild cognitive impairment compared to non-carriers.

Fiber in your diet reduces stroke risk

Analysis of eight studies on diet and stroke published between 1990 and 2012 has found that risk of first-time stroke dropped with every 7g increase in total daily fibre. That amount of fibre is contained in a bowl of wholewheat pasta plus two servings of fruit or vegetables.

Deep brain therapy effective in early Parkinson’s

A 2-year trial involving 251 patients with Parkinson's disease and early motor complications (mean age, 52 years; mean duration of disease, 7.5 years) has found that those given deep brain stimulation surgery significantly improved their quality of life, motor disability, activities of daily

Why high blood pressure can be so dangerous for memory

Brain scans of 61 older adults (65-90), of whom 30 were cognitively healthy, 24 cognitively impaired and 7 diagnosed with dementia, found that, across all groups, both memory and executive function correlated negatively with brain infarcts, many of which had been clinically silent.

Key attention region may underlie ‘super agers’ cognitive powers

A small study of “Super Agers” has found a key difference between them and typical older adults: an unusually large

Learning Facebook may keep seniors sharp

Preliminary findings from a small study show that older adults (68-91), after learning to use Facebook, performed about 25% better on tasks designed to measure their ability to continuously monitor and to quickly add or delete the contents of their

Pages