Brain networks disrupted in Alzheimer's disease

An analysis of the anatomical connectivity in the brains of 15 people with Alzheimer's disease, 68 with mild cognitive impairment and 28 healthy older individuals, has found several measures showed disease effects:

  • widespread network disruptions
  • decreases in network nodes
  • neural fiber path length
  • decreased signaling efficiency
  • increased asymmetry in the proportions of fibers that connect the left and right cortical regions

http://www.eurekalert.org/pub_releases/2013-08/mali-wgw082213.php

[3565] Daianu, M., Jahanshad N., Nir T. M., Toga A. W., Jack C. R., Weiner M. W., et al.
(2013).  Breakdown of Brain Connectivity Between Normal Aging and Alzheimer's Disease: A Structural k-Core Network Analysis.
Brain Connectivity. 3(4), 407 - 422.

Related News

Tau protein stabilizes structures that transport supplies from the center of the cell to the extremities, but sometimes some tau is not bound to these microtubules and instead clumps together into

A study involving genetically engineered fruit flies adds to our understanding of why sleep and bioclock disruptions are common in those with Alzheimer's disease.

A new study shows that a combination of inflammation and hypoxia activates microglia in a way that persistently weakens the connection between

A new function has been found for the

New research helps explain the role of amyloid-beta plaques in the development of Alzheimer's, by finding that the

Creating amyloid-beta requires the convergence of a protein called

A Swedish study of some 4,000 60-year-olds has found that regular “non-exercise” physical activity such as gardening or DIY significantly reduced risk of heart attack or stroke, with those who were most active on a daily basis having a 27% lower risk of a heart attack or stroke and a 30% reduced

A year-long study involving 424 sedentary, mobility-limited seniors aged 70-89, has found that variants in a specific gene (the ACE I/D gene) affect seniors’ ability to benefit from exercise.

Data from the American National Health and Nutrition Examination Survey (NHANES) III, involving 3,659 individuals (men aged 55+; women 65+), has found that the more muscle mass older adults have, the less likely they are to die prematurely.

A four-year study involving 1,502 healthy older adults (50+) has found that the frequency of negative interactions with family members (not partners or children) and friends was associated with an increased risk of developing hypertension in women (but not in men).

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news