A rat study using powerful imaging techniques has revealed how an injured brain continues to change long after the original trauma. Widespread decreases in brain functioning over a period of months were seen in specific brain regions, in particular the hippocampus, amygdala, and ipsilateral cortex, even when these were remote from the site of direct trauma and unaccompanied by signs of injury.
The findings indicate that there is a time window during which intervention could reduce these processes and protect against some of the disabling consequences of TBI.
 Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat. J Nucl Med [Internet]. 2010 ;51(11):1788 - 1795. Available from: http://jnm.snmjournals.org/cgi/content/abstract/51/11/1788