Prenatal exposure to common insecticide linked to lower IQ at age 7

May, 2011

Two longitudinal studies, one rural and one urban, have reported an association between prenatal pesticide exposure and significantly lower IQ at age 7.

A study of 265 New York City minority children has found that those born with higher amounts of the insecticide chlorpyrifos had lower IQ scores at age 7. Those most exposed (top 25%) scored an average 5.3 points lower on the working memory part of the IQ test (WISC-IV), and 2.7 points lower on the full IQ test, compared to those in the lowest quartile.

The children were born prior to the 2001 ban on indoor residential use of the common household pesticide in the US. The babies' umbilical cord blood was used to measure exposure to the insecticide.

Previous research had found that, prior to the ban, chlorpyrifos was detected in all personal and indoor air samples in New York, and 70% of umbilical cord blood collected from babies. The amount of chlorpyrifos in babies' blood was associated with neurodevelopmental problems at age three. The new findings indicate that these problems persist.

While exposure to the organophosphate has measurably declined, agricultural use is still permitted in the U.S.

Similarly, another study, involving 329 7-year-old children in a farming community in California, has found that those with the highest prenatal exposure to the pesticide dialkyl phosphate (DAP) had an average IQ 7 points lower than children whose exposure was in the lowest quintile. Prenatal pesticide exposure was linked to poorer scores for working memory, processing speed, verbal comprehension, and perceptual reasoning, as well as overall IQ.

Prenatal exposure was measured by DAP concentration in the mother’s urine. Urine was also collected from the children at age 6 months and 1, 2, 3½ and 5 years. However, there was no consistent link between children’s postnatal exposure and cognition.

While this was a farming community where pesticide exposure would be expected to be high, the levels were within the range found in the general population.

It’s recommended that people wash fruit and vegetables thoroughly, and limit their use of pesticides at home.

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