Obesity gene, carried by more than a third of the US population, leads to brain tissue loss

April, 2010
  • A variant of a gene called the fat mass and obesity associated (FTO) gene causes people to gain weight and puts them at risk for obesity.
  • A new study suggests that this gene variant is also associated with loss of brain tissue, in that, if you have this gene variant, your weight is associated with neuron loss, and if you don't, it isn’t.

A variant of a gene called the fat mass and obesity associated (FTO) gene causes people to gain weight and puts them at risk for obesity. The gene variant is found in nearly half of all people in the U.S. with European ancestry, around one-quarter of U.S. Hispanics, 15 percent of African Americans and 15 percent of Asian Americans. A new study involving 206 healthy elderly subjects from around the U.S. now suggests that this gene variant is also associated with loss of brain tissue. It’s not clear why, but the gene is highly expressed in the brain. Those with the "bad" version of the FTO gene had an average of 8% less tissue in the frontal lobes, and 12% less in the occipital lobes. The brain differences could not be directly attributed to other obesity-related factors (cholesterol levels, hypertension, or the volume of white matter hyperintensities), which didn’t vary between carriers and non-carriers. But if you have this gene variant, your weight is associated with neuron loss, and if you don't, it isn’t. The finding emphasizes the need for those with the gene to fight weight gain (and brain loss) by exercising and eating healthily.

Reference: 

Related News

A study involving healthy men and women fed a baseline diet containing 550 mg choline/day (the adequate intake level set by the Institute of Medicine) for 10 days, then put on a low choline diet (50 mg choline/day) for up to 42 days, has found that the "right" amount of choline depends on many f

A very large Italian study provides more evidence that the Mediterranean diet reduces inflammation, with their finding that those with a greater adherence to such a diet had significantly lower levels of platelets and white blood cells.

A 25-year study of diet and aging in 76 rhesus monkeys shows a significant reduction in mortality and in age-associated diseases among those on calorie-restricted diets.

Mice given decaffeinated green tea and regular exercise lost weight and improved their health after 16 weeks.

A mouse study suggests that merely changing meal times could have a significant effect on the levels of triglycerides in the liver. Levels of triglycerides followed a circadian rhythm, with levels peaking about eight hours after sunrise (note that mice are nocturnal).

A small trial involving seven older adults with insomnia has found that when they consumed 8 ounces of tart cherry juice twice daily for two weeks, they were able to sleep more than an hour longer each night (averaging 84 minutes) compared to when they took the placebo, and their sleep tended to

A study involving 61 women, of whom 33 were chronically stressed caring for a spouse or parent with dementia, has found that highly stressed people who ate a lot of high-fat, high-sugar food were likely to have:

A 2-year trial involving 59 patients with type 2 diabetes has found that those on a low-carbohydrate diet showed lower levels of inflammation compared with those on a traditional low-fat diet. Weight loss was similar in both groups.

Contradicting some earlier studies, new research using data from the very large and long-running Nurses' Health Study has found that calcium supplement intake was not associated with a higher risk of cardiovascular disease in women.

Preliminary studies have demonstrated that grape skin extract exerts a novel inhibitory activity on hyperglycemia and could be developed to aid in diabetes management.

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news
Error | About memory

Error

The website encountered an unexpected error. Please try again later.