Intensive hypertension treatment reduces risk of cognitive impairment

  • A large clinical trial comparing the effects on cardiovascular disease of standard blood pressure control vs stricter control, has found that stricter control significantly reduced the risk of mild cognitive impairment.

A clinical trial involving 9361 older adults (50+) with hypertension but without diabetes or history of stroke has found that intensive control of blood pressure significantly reduced the risk of developing mild cognitive impairment.

While there was also a 15% reduction in dementia, this result did not reach statistical significance. This may have been due to the small number of new cases of dementia in the study groups.

Participants were randomly assigned to a systolic blood pressure goal of either less than 120 mm HG (intensive treatment) or less than 140 mm HG (standard treatment). They were then classified after five years as having no cognitive impairment, MCI or probable dementia.

The trial was stopped early due to its success in reducing cardiovascular disease. As a result, participants were on intensive blood pressure lowering treatment for a shorter period than originally planned. This impacted the number of cases of dementia occurring.

Hypertension affects more than half of Americans over age 50 and more than 75% of those older than 65.

https://www.eurekalert.org/pub_releases/2019-01/wfbm-lbp012419.php

Reference: 

The SPRINT MIND Investigators for the SPRINT Research Group. (2019). Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA, 321(6), 553–561.

 

Related News

A small UK study involving 28 healthy older adults (20 women with average age 70; 8 men with average age 67), has found that those with higher levels of aerobic fitness experienced fewer language failures such as 'tip-of-the-tongue' states.

Findings from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) Study, which followed 2,802 healthy older adults for 10 years, has found that those who participated in computer training designed to improve processing speed and visual attention had a 29% lower risk of dev

An Australian study involving 102 older adults (60-90) has concluded that physical fitness and arterial stiffness account for a great deal of age-related memory decline.

A long-running study involving 454 older adults who were given physical exams and cognitive tests every year for 20 years has found that those who moved more than average maintained more of their cognitive skills than people who were less active than average, even if they have brain lesions or b

Data from the English Longitudinal Study of Aging, in which nearly 4,000 older adults (60+) had their walking speed assessed on two occasions in 2002-2003 and in 2004-2005, those with a slower walking speed were more likely to develop dementia in the next 10 years.

Exercise activates brain networks in older adults

A study involving healthy older adults (55-85) found that recall was better after a session of moderately intense exercise, and several crucial brain regions showed greater activation.

Lowering blood pressure prevents worsening brain damage in elderly

A study involving 54 older adults (55-80), who possessed at least one risk factor for a stroke, found that those with

Perivascular spaces are fluid-filled spaces around the cerebral small vessels, commonly seen on brain scans in older adults. They have been thought to be harmless, but a new study challenges this belief.

Data from 3,105 older adults (65+) who had either heart surgery or cardiac catheterization has found that those who had heart surgery didn’t experience much greater cognitive decline compared with those who had the much less invasive, catheter-based procedure.

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news