No evidence of Alzheimer’s pathology in younger carriers of Alzheimer’s gene

Two studies indicate that young people carrying the “Alzheimer’s gene” (ApoE4) do not have the pathological changes found later in life. The first study, involving 1412 adolescents, found no differences in hippocampal volume or asymmetry as a function of gene status. The second study, involving 173 young adults (average age, 28 ± 7.6 years), found no difference in plasma concentrations of amyloid-beta peptides.

[3583] Khan, W., Giampietro V., Ginestet C., Dell'Acqua F., Bouls D., Newhouse S., et al.
(2014).  No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents.
Journal of Alzheimer's Disease. 40(1), 37 - 43.

[3627] Zimmermann, R., Huber E., Schamber C., Lelental N., Mroczko B., Brandner S., et al.
(2014).  Plasma Concentrations of the Amyloid-β Peptides in Young Volunteers: The Influence of the APOE Genotype.
Journal of Alzheimer's Disease. 40(4), 1055 - 1060.