More on how amyloid-beta gets out of control

Creating amyloid-beta requires the convergence of a protein called amyloid precursor protein (APP) and an enzyme that cleaves APP into smaller toxic fragments (beta-secretase or BACE). Both APP and BACE are common in the brain, so why don’t we all get Alzheimer’s?

Cultured hippocampal neurons and tissue from human and mouse brains have now revealed that healthy brain cells largely segregate APP and BACE-1 into distinct compartments as soon as they are manufactured, ensuring the two proteins don’t have much contact with each other. However, in conditions promoting greater production of amyloid-beta protein (an increase in neuronal electrical activity), the convergence of APP and BACE also increases.

The findings not only add to our understanding of how Alzheimer’s gets started, but also suggests a possible therapeutic target: molecules that can physically keep APP and BACE-1 apart.

http://www.eurekalert.org/pub_releases/2013-08/uoc--wdw080213.php

http://www.alzforum.org/news/research-news/neural-activity-tips-endosomal-balance-hastens-amyloid-pathology

[3566] Das, U., Scott D. A., Ganguly A., Koo E. H., Tang Y., & Roy S.
(2013).  Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway.
Neuron. 79(3), 447 - 460.

Related News

Brain scans of 9,772 people aged 44 to 79, who were enrolled in the UK Biobank study, have revealed that smoking, high blood pressure, high pulse pressure, diabetes, and high BMI — but not high cholesterol — were all linked to greater brain shrinkage, less

A large Chinese study involving 20,000 people has found that the longer people were exposed to air pollution, the worse their cognitive performance in verbal and math tests. The effect of air pollution on verbal tests became more pronounced with age, especially for men and the less educated.

A review of 34 longitudinal studies, involving 71,244 older adults, has concluded that depression is associated with greater cognitive decline.

A study following nearly 28,000 older men for 20 years has found that regular consumption of leafy greens, dark orange and red vegetables and berry fruits, and orange juice, was associated with a lower risk of memory loss.

Poor sleep has been associated with the development of Alzheimer's disease, and this has been thought to be in part because the protein amyloid beta increases with sleep deprivation. A new study explains more.

A small study has found that a 12-week exercise program significantly improved cognition in both older adults with

A clinical trial involving 9361 older adults (50+) with hypertension but without diabetes or history of stroke has found that intensive control of blood pressure significantly reduced the risk of developing mild cognitive impairment.

Survey data from 6,807 Danish older adults (average age 60) in the Copenhagen City Heart Study, has found that being distressed in late midlife is associated with a higher risk of dementia in later life.

Poor sleep has been associated with Alzheimer's disease risk, but a new study suggests a specific aspect of sleep is important.

Data from 1,215 older adults, of whom 173 (14%) were African-American, has found that, although brain scans showed no significant differences between black and white participants,

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news