Epigenetic changes linked to type 2 diabetes

Analysis of insulin-producing cells has revealed that those with type 2 diabetes have epigenetic changes in approximately 800 genes, with altered gene expression in over 100 genes (many of them relating to insulin production).

Epigenetic changes occur as a result of factors including environment and lifestyle, and are reversible. A number of these changes were also found in place in healthy subjects as a result of age or high BMI, suggesting these changes could contribute to the development of the disease