Blocking inflammation receptor helps Alzheimer's mice

Blocking a receptor involved in inflammation in the brains of mice with severe Alzheimer’s produced marked recovery in blood flow and vascular reactivity, a dramatic reduction in toxic amyloid-beta, and significant improvements in learning and memory.

The receptor was the bradykinin B1 receptor (B1R), and the finding confirms a role of B1R, and neuroinflammation, in the development of Alzheimer’s. It also points to a new target for therapy.

[3585] Lacoste, B., Tong X-K., Lahjouji K., Couture R., & Hamel E.
(2013).  Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice.
Journal of Neuroinflammation. 10(1),