Blocking inflammation receptor helps Alzheimer's mice

Blocking a receptor involved in inflammation in the brains of mice with severe Alzheimer’s produced marked recovery in blood flow and vascular reactivity, a dramatic reduction in toxic amyloid-beta, and significant improvements in learning and memory.

The receptor was the bradykinin B1 receptor (B1R), and the finding confirms a role of B1R, and neuroinflammation, in the development of Alzheimer’s. It also points to a new target for therapy.

http://www.eurekalert.org/pub_releases/2013-06/mu-bor061713.php

[3585] Lacoste B, Tong X-K, Lahjouji K, Couture R, Hamel E. Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice. Journal of Neuroinflammation [Internet]. 2013 ;10(1). Available from: http://www.jneuroinflammation.com/content/10/1/57/abstract

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