Analysis shows 3 sub-types of type 2 diabetes

November, 2015

Medical and genetic data from thousands of patients has enabled researchers to compare the similarity between patients with type 2 diabetes, revealing three distinctive clusters. These sub-types of type 2 diabetes are associated with different genetic variants, and have quite different health implications.

Subtype 1 patients were more likely to suffer from well-known diabetes problems with kidneys and eyes (diabetic nephropathy and diabetic retinopathy); subtype 2 was more likely to suffer from cancer and cardiovascular diseases; and subtype 3 was associated most strongly with cardiovascular diseases, neurological diseases, allergies, and HIV infections.

http://www.fastcoexist.com/3052935/the-latest-breakthrough-in-understanding-diabetes-was-made-by-an-algorithm

Li, L., Cheng, W.-Y., Glicksberg, B. S., Gottesman, O., Tamler, R., Chen, R., … Dudley, J. T. (2015). Identification of type 2 diabetes subgroups through topological analysis of patient similarity. Science Translational Medicine, 7(311), 311ra174-311ra174. http://doi.org/10.1126/scitranslmed.aaa9364

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