seniors

Light drinking may protect brain function

A 10-year study involving 19,887 middle-aged and older Americans, who completed surveys every two years about their health and lifestyle, has found that those who had a drink or two a day tended to show less cognitive decline, compared to non-drinkers.

Cognitive function was measured in a series of tests looking at their overall mental status, word recall and vocabulary. Their test results were combined to form a total cognitive score.

Age, smoking and education level were controlled for.

However, it is still hard to say whether the link is causal or correlational. The researchers do not encourage anyone to start drinking in order to prevent cognitive function decline.

The association was also stronger among white participants versus African American participants, which perhaps adds weight to the view that the association is correlational, that is, linked to other behaviors which are the true reason.

Reference: 

Zhang R, Shen L, Miles T, et al. Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults. JAMA Netw Open. 2020;3(6):e207922. doi:10.1001/jamanetworkopen.2020.7922

Source: 

Topics: 

tags development: 

tags lifestyle: 

Higher aerobic fitness levels linked to fewer word failures in older adults

  • A small study found that aerobic fitness was linked to the frequency of tip-of-the-tongue occurrences in older adults.

A small UK study involving 28 healthy older adults (20 women with average age 70; 8 men with average age 67), has found that those with higher levels of aerobic fitness experienced fewer language failures such as 'tip-of-the-tongue' states.

The association between the frequency of tip-of-the-tongue occurrences (TOTs) and aerobic fitness levels existed even when age and vocabulary size was accounted for. Education level didn't affect TOTs, but only a few of the participants hadn't gone to university, so the study wasn't really in a position to test this out.

However, the larger the vocabulary for older adults, the less likely they were to have TOTs. Older adults also had more TOTs over longer words.

The test involved a 'definition filling task', in which they were asked to name famous people, such as authors, politicians and actors, based on 20 questions about them. They were also given the definitions of 20 'low frequency' and 20 'easy' words and asked whether they knew the word relating to the definition.

Aerobic fitness was assessed by a static bike cycling test.

The study included 27 young adults as a control group, to provide a comparison with older adults' language abilities, confirming that older adults did indeed have more TOTs. The young adults' fitness was not tested. All participants were monolingual.

https://www.eurekalert.org/pub_releases/2018-04/uob-haf042618.php

Reference: 

Segaert et al (2018). Higher physical fitness levels are associated with less language decline in healthy ageing. Scientific Reports. https://www.nature.com/articles/s41598-018-24972-1

Source: 

Topics: 

tags development: 

tags lifestyle: 

tags memworks: 

tags problems: 

This brain training program cuts dementia risk

  • A large 10-year study investigating the benefits of a brain training program for older adults found that training designed to improve processing speed & visual attention in particular reduced dementia risk.

Findings from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) Study, which followed 2,802 healthy older adults for 10 years, has found that those who participated in computer training designed to improve processing speed and visual attention had a 29% lower risk of developing dementia compared to controls, with more training producing lower risk. Those who received instruction in memory or reasoning strategies showed no change in dementia risk.

Participants were randomly placed into a control group or one of three different cognitive training groups. One was instructed in memory strategies, another in reasoning strategies, and one was given individualized, computerized speed of processing training.

There were 10 initial sessions of training, each 60 to 75 minutes, over six weeks. Participants were assessed at the beginning of the study, after the first six weeks, and at one, two, three, five, and 10 years. Some of each group received four additional “booster” training sessions in months 11 and 35.

Among those who completed the most sessions (5 or more booster sessions), indicators of dementia were evident in 5.9% of the computerized speed training group; 9.7% of the memory strategy group; 10.1% of the reasoning strategy group. The control group had a dementia incidence rate of 10.8%.

14% of those who received no training developed dementia in the next 10 years, compared with 12.1% of those who received the initial processing speed training, and 8.2% of those who also received the additional booster training.

A decade after training began, the scientists found that 22.7% of people in the speed training group had dementia, compared with 24.2% in both memory and reasoning groups. In a control group of people who had no training, the dementia rate was 28.8%. This effect is greater than the protection offered by antihypertensive medications against major cardiovascular events.

It's suggested that some of the reason for this effect may be that the training builds up brain reserve, perhaps by improving brain efficiency, or in some way improving the health of brain tissue.

Some of the participants told researchers that the training encouraged them to enroll in classes at a local college or keep driving, and it’s possible that the motivational boost for continued social and intellectual engagement might also help explain the benefits.

Other research has found that processing speed training is associated with a lower risk of depression and improved physical function, as well as better everyday functioning.

The processing speed training was designed to improve the speed and accuracy of visual attention, with both divided and selective attention exercises. To perform the divided attention training task, participants identified a central object—such as a truck—while simultaneously locating a target in the periphery—the car. The speed of these objects became increasingly faster as participants mastered each set. In the more difficult training tasks, adding distracting objects made the task even more challenging, thus engaging selective attention.

The training program is available as the “Double Decision” exercise in the BrainHQ.com commercial product.

Of the 1220 who completed the 10-year follow-up, 260 developed dementia during the period.

http://www.futurity.org/speed-of-processing-training-dementia-1613322/

https://www.eurekalert.org/pub_releases/2017-11/uosf-ibf111417.php

https://www.theguardian.com/society/2017/nov/16/can-brain-training-reduce-dementia-risk-despite-new-research-the-jury-is-still-out

http://www.scientificamerican.com/article/brain-training-cuts-dementia-risk-a-decade-later/

Reference: 

[4490] Edwards, J. D., Xu H., Clark D. O., Guey L. T., Ross L. A., & Unverzagt F. W.
(2017).  Speed of processing training results in lower risk of dementia.
Alzheimer's & Dementia: Translational Research & Clinical Interventions. 3(4), 603 - 611.

Full text available at https://www.trci.alzdem.com/article/S2352-8737(17)30059-8/fulltext

Source: 

Topics: 

tags development: 

tags lifestyle: 

tags problems: 

tags strategies: 

Better physical fitness and lower aortic stiffness key to slower brain aging

  • A study found that physical fitness & arterial stiffness accounted for a third of the cognitive differences between older adults, completely erasing age as a factor.

An Australian study involving 102 older adults (60-90) has concluded that physical fitness and arterial stiffness account for a great deal of age-related memory decline.

The study that, while both physical fitness and aortic stiffness were associated with spatial working memory performance, the two factors affected cognition independently. More importantly, and surprisingly, statistical modelling found that, taking BMI and gender into account, fitness and aortic stiffness together explained a third (33%) of the individual differences in spatial working memory — with age no longer predicting any of the differences.

While physical fitness didn’t seem to affect central arterial stiffness, the researchers point out that only current fitness was assessed and long term fitness might be a better predictor of central arterial stiffness.

It's also worth noting that only one cognitive measure was used. However, this particular measure should be a good one for assessing cognition untainted by the benefits of experience — a purer measure of the ability to process information, as it were.

It would also be interesting to extend the comparison to younger adults. I hope future research will explore these aspects.

Nevertheless, the idea that age-related cognitive decline might be largely, or even entirely, accounted for by one's physical fitness and the state of one's arteries, is an immensely appealing one.

Fitness was assessed with the Six-Minute Walk test which involved participants walking back and forth between two markers placed 10 metres apart for six minutes. Only participants who completed the full six minutes were included in the analysis.

https://www.eurekalert.org/pub_releases/2018-06/ip-bpf061118.php

Reference: 

Source: 

Topics: 

tags development: 

tags lifestyle: 

tags problems: 

Moving more in old age may protect brain from dementia

  • A long-running study found older adults who moved more were less likely to develop dementia, even when they had brain pathologies characteristic of dementia.

A long-running study involving 454 older adults who were given physical exams and cognitive tests every year for 20 years has found that those who moved more than average maintained more of their cognitive skills than people who were less active than average, even if they have brain lesions or biomarkers linked to dementia.

Participants wore an activity monitor for a week, an average of two years before death. The range of physical activity was extreme, with the average being 155,000 counts/day and the standard deviation being 116,000 counts. Daily physical activity was affected by age (unsurprisingly) and education.

For every increase in physical activity by one standard deviation, participants were 31% less likely to develop dementia. For every increase in motor ability by one standard deviation, participants were 55% less likely to develop dementia.

191 had dementia and 263 did not. The participants donated their brains for research upon their deaths. The average age at death was 91 years. Almost all (95.6%) showed at least one brain pathology, with 85% having at least two, and the average being three. Pathologies include Alzheimer's pathology, Lewy Bodies, nigral neuronal loss, TDP-43, hippocampal sclerosis, micro- and macro-infarcts, atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy.

https://www.eurekalert.org/pub_releases/2019-01/rumc-mmi011119.php

https://www.theguardian.com/science/2019/jan/16/activity-sharpens-even-dementia-affected-brains-report-suggests

Reference: 

Buchman, Aron S. et al. 2019. Physical activity, common brain pathologies, and cognition in community-dwelling older adults. Neurology, 92 (8), e811-e822; DOI: 10.1212/WNL.0000000000006954

Source: 

Topics: 

tags development: 

tags lifestyle: 

tags problems: 

Slower walking speeds linked to dementia risk

  • A large, long-running study has found older adults with a slower walking speed were more likely to develop dementia in the next decade.
  • Another long-running study has found that slowing over 14 years was linked to brain atrophy in the hippocampus, and cognitive impairment.

Data from the English Longitudinal Study of Aging, in which nearly 4,000 older adults (60+) had their walking speed assessed on two occasions in 2002-2003 and in 2004-2005, those with a slower walking speed were more likely to develop dementia in the next 10 years. Those who experienced a faster decline in walking speed over the two-year period were also more likely to develop dementia.

https://www.eurekalert.org/pub_releases/2018-03/ags-oaw032318.php

A long-running study involving 175 older adults (70-79) found that slowing in walking speed over a 14-year period was associated with cognitive impairment, and with shrinkage of the right hippocampus specifically.

Gait slowing over an extended period of time was a stronger predictor of cognitive decline than slowing at a single time point. All the participants slowed over time, but those who slowed by 0.1 seconds more per year than their peers were 47% more likely to develop cognitive impairment.

The finding held even when the researchers took into account slowing due to muscle weakness, knee pain and diseases, including diabetes, heart disease, and hypertension.

Typically, a slowing gait is seen as a physical issue, but doctors should consider that there may be a brain pathology driving it.

http://www.futurity.org/gait-hippocampus-brains-dementia-1472892/

Reference: 

Source: 

Topics: 

tags development: 

tags lifestyle: 

tags problems: 

Physical activity linked to better brain health & cognition in older adults

  • A study found that older adults remembered names better after moderately intense exercise.
  • A large, long-running study found that each hour of light physical activity per week was linked to less brain atrophy.
  • Similarly, another long-running study reported that higher levels of lifestyle physical activity were associated with less brain atrophy.

Exercise activates brain networks in older adults

A study involving healthy older adults (55-85) found that recall was better after a session of moderately intense exercise, and several crucial brain regions showed greater activation.

The recall task involved identifying famous names and non famous ones. The test occurred 30 minutes after the exercise session (using an exercise bike) and on a separate day after a period of rest.

Brain activation while correctly remembering names was significantly greater in the hippocampus, middle frontal gyrus, inferior temporal gryus, middle temporal gyrus, and fusiform gyrus.

https://www.eurekalert.org/pub_releases/2019-04/uom-eam042419.php

Light, physical activity reduces brain aging

Data from the Framingham Heart Study has found that each additional hour spent in light-intensity physical activity was associated with higher brain volumes, equivalent to approximately 1.1 years less brain aging.

https://www.eurekalert.org/pub_releases/2019-04/buso-lpa041719.php

https://www.theguardian.com/science/2019/apr/19/household-chores-keep-brain-young-research-suggests

Everyday physical activities linked to more gray matter in brains of older adults

Data from 262 older adults (mean age 81) in the long-running Rush's Memory and Aging Project, found that higher levels of lifestyle physical activity (e.g., house cleaning, dog-walking, gardening, as well as exercise) are associated with more gray matter.

Participants wore an accelerometer continuously for seven to ten days, in order to accurately measure the frequency, duration and intensity of a participant's activities.

The association between physical activity and gray matter volumes remained after further controlling for age, gender, education levels, body mass index and symptoms of depression.

https://www.eurekalert.org/pub_releases/2018-02/rumc-eaa021318.php

Reference: 

Source: 

Topics: 

tags development: 

tags lifestyle: 

Higher blood pressure linked to greater brain damage in older adults

  • A clinical trial found that hypertensive older adults who took medication to keep their systolic blood pressure around 130 showed markedly fewer white matter lesions than those maintaining a level of 145.
  • A large, long-running study found that higher blood pressiure was linked to more brain lesions and more tau tangles.
  • A long-running study found that both higher amyloid-beta levels and higher vascular risk were linked to faster cognitive decline, with the factors interacting to be worse than additive.

Lowering blood pressure prevents worsening brain damage in elderly

A clinical trial involving 199 hypertensive older adults (average age 81) found that those who took medicine to keep their 24-hour systolic blood pressure around 130 mm Hg for three years showed 40% less accumulation of white matter lesions compared with those taking medicine to maintain a systolic blood pressure around 145 mm Hg.

60% of the patients maintained their target blood pressure throughout the full three years, and data from these alone showed an even bigger difference in number of brain lesions.

The study used around-the-clock ambulatory blood pressure monitors, which measured participants' blood pressure during all activities of daily living.

Participants had an average systolic blood pressure around 150 mm Hg at the beginning of the trial.

The research was presented at the American College of Cardiology's 68th Annual Scientific Session.

https://www.eurekalert.org/pub_releases/2019-03/acoc-lbp031819.php

Brain lesions linked to higher blood pressure in older adults

A long-running study tracking 1,288 older adults (65+) until their deaths found that the risk and number of brain lesions increased with higher blood pressure. High blood pressure was also linked to increased risk of protein tangles in the brain.

Two-thirds of the subjects had high blood pressure, while about half had one or more brain infarcts. Those with an upper blood pressure of 147 had a 46% higher chance of having one or more lesions.

https://www.the-scientist.com/news-opinion/higher-blood-pressure-has-links-to-brain-lesions-in-older-adults-64495

Vascular risk interacts with amyloid levels to increase age-related cognitive decline

Data from 223 participants in the Harvard Aging Brain Study found that both elevated brain amyloid levels and higher vascular risk were associated with more rapid cognitive decline, with the most rapid changes seen in those with both factors. The interaction between the two factors appears to be synergistic rather than simply additive — that is, the interaction between vascular factors and amyloid burden produces more risk than would be predicted from simply adding the two together.

https://www.eurekalert.org/pub_releases/2018-05/mgh-vri052118.php

Reference: 

Arvanitakis, Z., Capuano, A. W., Lamar, M., Shah, R. C., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2018). Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology. Neurology, 91(6), e517. https://doi.org/10.1212/WNL.0000000000005951

[4499] Rabin, J. S., Schultz A. P., Hedden T., Viswanathan A., Marshall G. A., Kilpatrick E., et al.
(2018).  Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study.
JAMA Neurology. 75(9), 1124 - 1131.

Topics: 

tags development: 

tags problems: 

Absentmindedness can be an early warning sign of silent strokes

  • A small study found that older adults with white matter damage caused by silent strokes noticed poorer attention and distractability.

A study involving 54 older adults (55-80), who possessed at least one risk factor for a stroke, found that those with white matter damage caused by silent strokes reported poor attentiveness and being distracted more frequently on day-to-day tasks. Despite these complaints, about half of these people scored within the normal range on tests of attention and executive function.

It’s suggested that adults who notice that they frequently lose their train of thought or often become sidetracked may in fact be displaying early symptoms of cerebral small vessel disease.

"Silent" strokes are so-called because they don’t have obvious effects as seen with an overt stroke. Typically, they’re not diagnosed until the damage has accumulated to such an extent that effects are seen, or by chance through MRI scans.

https://www.eurekalert.org/pub_releases/2019-02/bcfg-apt020419.php

Reference: 

Dey, A. K., Stamenova, V., Bacopulos, A., Jeyakumar, N., Turner, G. R., Black, S. E., & Levine, B. (2019). Cognitive heterogeneity among community-dwelling older adults with cerebral small vessel disease. Neurobiology of Aging, 77, 183–193. https://doi.org/10.1016/j.neurobiolaging.2018.12.011

Source: 

Topics: 

tags development: 

tags problems: 

Perivascular space size linked to cognitive impairment in older adults

  • Enlarged perivascular spaces have been linked to poorer processing speed and executive functioning in older adults.

Perivascular spaces are fluid-filled spaces around the cerebral small vessels, commonly seen on brain scans in older adults. They have been thought to be harmless, but a new study challenges this belief.

The study, which looked at older adults who have not yet developed dementia, showed that different markers of small vessel disease reflect distinct pathways of injury. Well-studied markers of small vessel disease include white matter hyperintensities, infarcts and microbleeds, and the most frequent associations in the study unsurprisingly linked white matter hyperintensities and cognition, including language, information processing speed, executive functioning and visuospatial skills.

Much more surprisingly, though, the next most frequent links were between enlarged perivascular spaces and information processing speed and executive functioning.

https://www.eurekalert.org/pub_releases/2019-03/vumc-sv032019.php

Reference: 

Topics: 

tags development: 

tags problems: 

Pages

Subscribe to RSS - seniors