Severe, rapid memory loss linked to future, fatal strokes

March, 2012

A large, long-running study has revealed that older adults who suffered a fatal stroke showed significantly faster cognitive decline in the years preceding the stroke compared to stroke survivors and stroke-free adults.

A ten-year study following 12,412 middle-aged and older adults (50+) has found that those who died after stroke had more severe memory loss in the years before stroke compared to those who survived stroke and those who didn't have a stroke.

Participants were tested every two years, using a standard word-recall list to measure memory loss (or caregiver assessment for those whose memory loss was too severe). During the decade of the study, 1,027 participants (8.3%) survived a stroke, 499 (4%) died after stroke, and 10,886 (87.7%) remained stroke-free over the study period.

Before having a stroke, those who later survived a stroke had worse average memory than similar individuals who never had a stroke, however their rate of memory decline was similar (0.034 and 0.028 points per year, respectively). Those who later died after a stroke, on the other hand, showed significantly faster memory decline (0.118 points per year).

Whether this is because those who die after stroke have a more compromised brain prior to the stroke, or because greater memory impairment makes people more vulnerable in the wake of a stroke, cannot be told from this data (and indeed, both factors may be involved).

Among survivors, stroke had a significant effect on memory decline, with memory scores dropping an average of 0.157 points at the time of the stroke — an amount equivalent to around 5.6 years of memory decline in similarly-aged stroke-free adults. However, in subsequent years, decline was only a little greater than it had been prior to the stroke (0.038 points per year).

(You can see a nice graph of these points here.)

Reference: 

Wang, Q., Capistrant, B.D., Ehntholt, A. & Glymour, M.M. 2012. Abstract 31: Rate of Change in Memory Functioning Before and After Stroke Onset. Presented at the American Stroke Association's International Stroke Conference 2012. http://stroke.ahajournals.org/cgi/content/meeting_abstract/43/2_MeetingAbstracts/A31?sid=960f2015-06d1-478f-8c03-c00994d35f2c

Related News

While everyone agrees that amyloid-beta protein is part of the problem, not everyone agrees that amyloid plaques are the cause (or one of them) of Alzheimer’s. Other forms of amyloid-beta have been pointed to, including floating clumps called oligomers or ADDLs.

A few months ago, I reported on an exciting finding that

The American Academy of Neurology has updated its guidelines on when people with dementia should stop driving.

Another gene has been identified that appears to increase risk of Alzheimer’s. The gene, MTHFD1L, is located on chromosome six.

Previous research has found that unexplained weight loss is an early sign of Alzheimer's.

Amnestic mild cognitive impairment often leads to Alzheimer's disease, but what predicts aMCI?

A pilot study involving 21 institutionalized individuals with moderate-to-severe Alzheimer’s found that, although drinking two 4-oz glasses of apple juice daily for a month produced no change in the Dementia Rating Scale or in the Activities of Daily Living measure, there was a significant (27%)

A pilot study involving 10 patients with moderate Alzheimer's disease, of whom half were randomly assigned to the treatment, has found that two weeks of receiving daily (25 minute) periods of repetitive transcranial magnetic stimulation to the prefrontal

A study involving outpatients with early stage Alzheimer’s found that their performance on some computerized tests of executive function and visual attention, including a simulated driving task, improved significantly after three months of taking

A study involving 54 older adults (66-76) and 58 younger adults (18-35) challenges the idea that age itself causes people to become more risk-averse and to make poorer decisions.

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news