Review confirms early diagnosis tool

February, 2010

A comprehensive survey confirms the value of an early diagnostic tool, and provides strong evidence for the central importance of amyloid-beta protein plaques in the development of Alzheimer’s.

A survey of more than 100 studies involving PIB-PET, a diagnostic tool that involves injecting a radiotracer called Pittsburgh compound B into the brain via the bloodstream, and imaging the brain with positron emission tomography (PET), has confirmed its sensitivity in detecting amyloid-beta protein plaques. The tool is not yet commercially available. The study also provides strong evidence supporting the theory that accumulation of amyloid-beta protein plaques in the brain is central to the development of Alzheimer’s. The findings, that amyloid deposits appear to reach a plateau early in the disease course, may explain why Alzheimer's patients have not responded to promising experimental drugs that target amyloid. It may be that they are being administered too late.

Reference: 

Related News

Functional impairment good indicator of mild cognitive impairment

Following on from research showing that long-term meditation is associated with gray matter increases across the brain, an imaging study involving 27 long-term meditators (average age 52) and 27 controls (matched by age and sex) has revealed pronounced differences in white-matter connectivity be

Another study showing the value of exercise for preserving your mental faculties in old age.

It wasn’t so long ago we believed that only young brains could make neurons, that once a brain was fully matured all it could do was increase its connections. Then we found out adult brains could make new neurons too (but only in a couple of regions, albeit critical ones).

The brain tends to shrink with age, with different regions being more affected than others. Atrophy of the

A number of studies have demonstrated the cognitive benefits of music training for children. Now research is beginning to explore just how long those benefits last.

As we get older, when we suffer memory problems, we often laughingly talk about our brain being ‘full up’, with no room for more information. A new study suggests that in some sense (but not the direct one!) that’s true.

I commonly refer to ApoE4 as the ‘Alzheimer’s gene’, because it is the main genetic risk factor, tripling the risk for getting Alzheimer's. But it is not the only risky gene.

For the first time in 27 years, clinical diagnostic criteria for Alzheimer's disease dementia have been revised, and research guidelines updated. They mark a major change in how experts think about and study Alzheimer's disease.

A long-term study of older adults with similar levels of education has found that those with the thinnest

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news