Review confirms early diagnosis tool

February, 2010

A comprehensive survey confirms the value of an early diagnostic tool, and provides strong evidence for the central importance of amyloid-beta protein plaques in the development of Alzheimer’s.

A survey of more than 100 studies involving PIB-PET, a diagnostic tool that involves injecting a radiotracer called Pittsburgh compound B into the brain via the bloodstream, and imaging the brain with positron emission tomography (PET), has confirmed its sensitivity in detecting amyloid-beta protein plaques. The tool is not yet commercially available. The study also provides strong evidence supporting the theory that accumulation of amyloid-beta protein plaques in the brain is central to the development of Alzheimer’s. The findings, that amyloid deposits appear to reach a plateau early in the disease course, may explain why Alzheimer's patients have not responded to promising experimental drugs that target amyloid. It may be that they are being administered too late.

http://www.eurekalert.org/pub_releases/2010-02/uoc--nsm020910.php

Reference:

[182] Rabinovici, G. D., & Jagust W. J.
(2009). Amyloid imaging in aging and dementia: Testing the amyloid hypothesis in vivo.
Behavioural Neurology. 21(1), 117 - 128.

seniors

alzheimers-diagnosis

Alzheimers

Related News

For the brain, iron levels may need to be just right

Iron deficiency is the world's single most common nutrient deficiency, and a well-known cause of impaired cognitive, language, and motor development. Many countries therefore routinely supplement infant foods with iron.

Why a select group of seniors retain their cognitive abilities

A certain level of mental decline in the senior years is regarded as normal, but some fortunate few don’t suffer from any decline at all.

Memory genes vary in protecting against age-related cognitive decline

Previous research has found that carriers of the so-called

Obesity linked to better cognition in post-menopausal women

Obesity has been linked to cognitive decline, but a new study involving 300 post-menopausal women has found that higher BMI was associated with higher cognitive scores.

How neighborhood status affects cognitive function in older adults

In the last five years, three studies have linked lower neighborhood socioeconomic status to lower cognitive function in older adults. Neighborhood has also been linked to self-rated health, cardiovascular disease, and mortality.

Which 'Senior moments' may signal mental decline

A telephone survey of around 17,000 older women (average age 74), which included questions about memory lapses plus standard cognitive tests, found that getting lost in familiar neighborhoods was highly associated with cognitive impairment that might indicate Alzheimer’s.

Timing of estrogen therapy is crucial

The very large and long-running Women's Health Initiative study surprised everyone when it produced its finding that hormone therapy generally increased rather than decreased stroke risk as well as other health problems.

When age helps decision making

Research has shown that younger adults are better decision makers than older adults — a curious result. A new study tried to capture more ‘real-world’ decision-making, by requiring participants to evaluate each result in order to strategize the next choice.

Memory fitness program improves memory abilities of oldest adults

In a study involving 115 seniors (average age 81), those who participated in a six-week, 12-session memory training program significantly improved their verbal memory.

Errorless learning not always best for older brains

Following a 1994 study that found that errorless learning was better than trial-and-error learning for amnesic patients and older adults, errorless learning has been widely adopted in the rehabilitation industry.

Pages