Improving fitness may counteract brain atrophy in older adults, including those with MCI

  • A small study involving physically inactive older adults found that a three-month exercise program reversed some brain atrophy.

A study involving 30 previously physically inactive older adults (aged 61-88) found that a three-month exercise program reversed some brain atrophy.

Participants included 14 with MCI. The exercise program included moderate intensity walking on a treadmill four times a week over a twelve-week period. On average, cardiorespiratory fitness improved by about 8% as a result of the training in both the healthy and MCI participants. Fitness was assessed using peak oxygen capacity rates.

Those who showed the greatest improvements in fitness had the most growth in cortical thickness. Those with MCI showed greater improvements compared to healthy group in the left insula and superior temporal gyrus, two brain regions that have been shown to exhibit accelerated neurodegeneration in Alzheimer’s disease.

http://www.eurekalert.org/pub_releases/2015-11/uom-ifm111915.php

Reference: 

Reiter, K., Nielson, K. A., Smith, T. J., Weiss, L. R., Alfini, A. J., & Smith, J. C. (2015). Improved Cardiorespiratory Fitness Is Associated with Increased Cortical Thickness in Mild Cognitive Impairment. Journal of the International Neuropsychological Society, 21(Special Issue 10), 757–767. https://doi.org/10.1017/S135561771500079X

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