Sleep deprivation

Chronic sleep disturbance could trigger onset of Alzheimer's

A mouse study has found that mice (genetically engineered for Alzheimer’s) who were sleep deprived for eight weeks, not only showed significant cognitive impairment, but also showed a significant increase in the amount of tau protein that became phosphorylated and formed tangles. The other main characteristic of Alzheimer’s, amyloid-beta plaques, was not affected.

The findings are consistent with growing evidence of a link between sleep disturbance and Alzheimer’s, and suggests that chronic sleep disturbance accelerates Alzheimer’s pathology, and should be treated.

The sleep-deprived mice were given 20 hours of light each day, while the control mice were kept on a schedule of 12 hours of light and 12 hours of darkness.

http://www.eurekalert.org/pub_releases/2014-03/tu-csd031714.php

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Broken bioclock linked to Alzheimer's-type brain damage

A study involving mice lacking a master clock gene called Bmal1 has found that as the mice aged, their brains showed patterns of damage similar to those seen in Alzheimer's disease and other neurodegenerative disorders. Many of the injuries seemed to be caused by free radicals.

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Sleep apnea linked to Alzheimer’s risk

An Italian study has found that a significant percentage of Alzheimer’s patients suffer from Obstructive Sleep Apnea Syndrome. This respiratory disorder, which causes people to temporarily stop breathing during their sleep, affects cerebral blood flow, promoting cognitive decline. The finding adds to evidence that detecting and treating OSA early is important for preventing cognitive decline and dementia.

http://www.eurekalert.org/pub_releases/2013-10/ip-apn100813.php

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Poorer sleep linked to Alzheimer plaques

Data from 70 older adults (average age 76) in the Baltimore Longitudinal Study of Aging has found that those who reported poorer sleep (shorter sleep duration and lower sleep quality) showed a greater buildup of amyloid-beta plaques.

http://www.eurekalert.org/pub_releases/2013-10/tjnj-lsa101813.php

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Why sleep is disrupted in Alzheimer's disease

A study involving genetically engineered fruit flies adds to our understanding of why sleep and bioclock disruptions are common in those with Alzheimer's disease. People with Alzheimer's often have poor biological rhythms — periods of sleep become shorter and more fragmented, resulting in periods of wakefulness at night and snoozing during the day. It has been thought that Alzheimer’s destroys the biological clock, but this new study indicates that the clock is still working — however, it’s being ignored by other parts of the brain.

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Even moderate weight loss can help obstructive sleep apnea

A Finnish study involving moderately obese adult patients with mild obstructive sleep apnea (OSA) has found that even a modest weight loss (5%) can improve OSA, if occurring in the early stages of OSA.

http://www.eurekalert.org/pub_releases/2014-02/uoef-emw021114.php

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Higher levels of omega-3 in diet associated with better sleep

A study involving 362 children with reading problems has found that 16 weeks of daily 600 mg supplements of omega-3 DHA from algal sources improved their sleep. According to a sleep questionnaire filled out by parents, 40% of these children had significant sleep problems. Monitoring of 43 of the poor sleepers found that children taking daily supplements of omega-3 had nearly one hour (58 minutes) more sleep and seven fewer waking episodes per night compared with children taking a placebo.

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