Latest Research News
A meta-analysis of studies reporting brain activity in individuals with a diagnosis of PTSD has revealed differences between the brain activity of individuals with PTSD and that of groups of both trauma-exposed (those who had experienced trauma but didn't have a diagnosis of PTSD) and trauma-naïve (those who hadn't experienced trauma) participants.
The critical difference between those who developed PTSD and those who experienced trauma but didn't develop PTSD lay in the basal ganglia. Specifically:
- PTSD brains compared with trauma-exposed controls showed differentially active regions of the basal ganglia
- trauma-exposed brains compared with trauma-naïve controls revealed differences in the right anterior insula, precuneus, cingulate and orbitofrontal cortices, all known to be involved in emotional regulation
- PTSD brains compared with both control groups showed differences in activity in the amygdala and parahippocampal cortex.
The finding is consistent with other new evidence from the researchers, that other neuropsychiatric disorders were also associated with specific imbalances in specific brain networks.
The findings suggest that, while people who have experienced trauma may not meet the threshold for a diagnosis of PTSD, they may have similar changes within the brain, which might make them more vulnerable to PTSD if they experience a subsequent trauma.
The finding also suggests a different perspective on PTSD — that it “may not actually be abnormal or a 'disorder' but the brain's natural reaction to events and experiences that are abnormal”.
 . Post-traumatic stress influences the brain even in the absence of symptoms: A systematic, quantitative meta-analysis of neuroimaging studies. Neuroscience & Biobehavioral Reviews [Internet]. 2015 ;56:207 - 221. Available from: http://www.sciencedirect.com/science/article/pii/S014976341500192X
More evidence that even an 8-week meditation training program can have measurable effects on the brain comes from an imaging study. Moreover, the type of meditation makes a difference to how the brain changes.
The study involved 36 participants from three different 8-week courses: mindful meditation, compassion meditation, and health education (control group). The courses involved only two hours class time each week, with meditation students encouraged to meditate for an average 20 minutes a day outside class. There was a great deal of individual variability in the total amount of meditation done by the end of the course (210-1491 minutes for the mindful attention training course; 190-905 minutes for the compassion training course).
Participants’ brains were scanned three weeks before the courses began, and three weeks after the end. During each brain scan, the volunteers viewed 108 images of people in situations that were either emotionally positive, negative or neutral.
In the mindful attention group, the second brain scan showed a decrease in activation in the right amygdala in response to all images, supporting the idea that meditation can improve emotional stability and response to stress. In the compassion meditation group, right amygdala activity also decreased in response to positive or neutral images, but, among those who reported practicing compassion meditation most frequently, right amygdala activity tended to increase in response to negative images. No significant changes were seen in the control group or in the left amygdala of any participant.
The findings support the idea that meditation can be effective in improving emotional control, and that compassion meditation can indeed increase compassionate feelings. Increased amygdala activation was also correlated with decreased depression scores in the compassion meditation group, which suggests that having more compassion towards others may also be beneficial for oneself.
The findings also support the idea that the changes brought about by meditation endure beyond the meditative state, and that the changes can start to occur quite quickly.
These findings are all consistent with other recent research.
One point is worth emphasizing, in the light of the difficulty in developing a training program that improves working memory rather than simply improving the task being practiced. These findings suggest that, unlike most cognitive training programs, meditation training might produce learning that is process-specific rather than stimulus- or task-specific, giving it perhaps a wider generality than most cognitive training.
 . Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Frontiers in Human Neuroscience [Internet]. 2012 ;6. Available from: http://www.frontiersin.org/human_neuroscience/10.3389/fnhum.2012.00292/abstract
Full text available at http://www.frontiersin.org/human_neuroscience/10.3389/fnhum.2012.00292/a...
We know that emotion affects memory. We know that attention affects perception (see, e.g., Visual perception heightened by meditation training; How mindset can improve vision). Now a new study ties it all together. The study shows that emotionally arousing experiences affect how well we see them, and this in turn affects how vividly we later recall them.
The study used images of positively and negatively arousing scenes and neutral scenes, which were overlaid with varying amounts of “visual noise” (like the ‘snow’ we used to see on old televisions). College students were asked to rate the amount of noise on each picture, relative to a specific image they used as a standard. There were 25 pictures in each category, and three levels of noise (less than standard, equal to standard, and more than standard).
Different groups explored different parameters: color; gray-scale; less noise (10%, 15%, 20% as compared to 35%, 45%, 55%); single exposure (each picture was only presented once, at one of the noise levels).
Regardless of the actual amount of noise, emotionally arousing pictures were consistently rated as significantly less noisy than neutral pictures, indicating that people were seeing them more clearly. This was true in all conditions.
Eye-tracking analysis ruled out the idea that people directed their attention differently for emotionally arousing images, but did show that more eye fixations were associated both with less noisy images and emotionally arousing ones. In other words, people were viewing emotionally important images as if they were less noisy.
One group of 22 students were given a 45-minute spatial working memory task after seeing the images, and then asked to write down all the details they could remember about the pictures they remembered seeing. The amount of detail they recalled was taken to be an indirect measure of vividness.
A second group of 27 students were called back after a week for a recognition test. They were shown 36 new images mixed in with the original 75 images, and asked to rate them as new, familiar, or recollected. They were also asked to rate the vividness of their recollection.
Although, overall, emotionally arousing pictures were not more likely to be remembered than neutral pictures, both experiments found that pictures originally seen as more vivid (less noise) were remembered more vividly and in more detail.
Brain scans from 31 students revealed that the amygdala was more active when looking at images rated as vivid, and this in turn increased activity in the visual cortex and in the posterior insula (which integrates sensations from the body). This suggests that the increased perceptual vividness is not simply a visual phenomenon, but part of a wider sensory activation.
There was another neural response to perceptual vividness: activity in the dorsolateral prefrontal cortex and the posterior parietal cortex was negatively correlated with vividness. This suggests that emotion is not simply increasing our attentional focus, it is instead changing it by reducing effortful attentional and executive processes in favor of more perceptual ones. This, perhaps, gives emotional memories their different ‘flavor’ compared to more neutral memories.
These findings clearly need more exploration before we know exactly what they mean, but the main finding from the study is that the vividness with which we recall some emotional experiences is rooted in the vividness with which we originally perceived it.
The study highlights how emotion can sharpen our attention, building on previous findings that emotional events are more easily detected when visibility is difficult, or attentional demands are high. It is also not inconsistent with a study I reported on last year, which found some information needs no repetition to be remembered because the amygdala decrees it of importance.
I should add, however, that the perceptual effect is not the whole story — the current study found that, although perceptual vividness is part of the reason for memories that are vividly remembered, emotional importance makes its own, independent, contribution. This contribution may occur after the event.
It’s suggested that individual differences in these reactions to emotionally enhanced vividness may underlie an individual’s vulnerability to post-traumatic stress disorder.
 . Psychophysical and Neural Evidence for Emotion-Enhanced Perceptual Vividness. The Journal of Neuroscience [Internet]. 2012 ;32(33):11201 - 11212. Available from: http://www.jneurosci.org/content/32/33/11201
This is another demonstration of stereotype threat, which is also a nice demonstration of the contextual nature of intelligence. The study involved 70 volunteers (average age 25; range 18-49), who were put in groups of 5. Participants were given a baseline IQ test, on which they were given no feedback. The group then participated in a group IQ test, in which 92 multi-choice questions were presented on a monitor (both individual and group tests were taken from Cattell’s culture fair intelligence test). Each question appeared to each person at the same time, for a pre-determined time. After each question, they were provided with feedback in the form of their own relative rank within the group, and the rank of one other group member. Ranking was based on performance on the last 10 questions. Two of each group had their brain activity monitored.
Here’s the remarkable thing. If you gather together individuals on the basis of similar baseline IQ, then you can watch their IQ diverge over the course of the group IQ task, with some dropping dramatically (e.g., 17 points from a mean IQ of 126). Moreover, even those little affected still dropped some (8 points from a mean IQ of 126).
Data from the 27 brain scans (one had to be omitted for technical reasons) suggest that everyone was initially hindered by the group setting, but ‘high performers’ (those who ended up scoring above the median) managed to largely recover, while ‘low performers’ (those who ended up scoring below the median) never did.
Personality tests carried out after the group task found no significant personality differences between high and low performers, but gender was a significant variable: 10/13 high performers were male, while 11/14 low performers were female (remember, there was no difference in baseline IQ — this is not a case of men being smarter!).
There were significant differences between the high and low performers in activity in the amygdala and the right lateral prefrontal cortex. Specifically, all participants had an initial increase in amygdala activation and diminished activity in the prefrontal cortex, but by the end of the task, the high-performing group showed decreased amygdala activation and increased prefrontal cortex activation, while the low performers didn’t change. This may reflect the high performers’ greater ability to reduce their anxiety. Activity in the nucleus accumbens was similar in both groups, and consistent with the idea that the students had expectations about the relative ranking they were about to receive.
It should be pointed out that the specific feedback given — the relative ranking — was not a factor. What’s important is that it was being given at all, and the high performers were those who became less anxious as time went on, regardless of their specific ranking.
There are three big lessons here. One is that social pressure significantly depresses talent (meetings make you stupid?), and this seems to be worse when individuals perceive themselves to have a lower social rank. The second is that our ability to regulate our emotions is important, and something we should put more energy into. And the third is that we’ve got to shake ourselves loose from the idea that IQ is something we can measure in isolation. Social context matters.
 . Implicit signals in small group settings and their impact on the expression of cognitive capacity and associated brain responses. Philosophical Transactions of the Royal Society B: Biological Sciences [Internet]. 2012 ;367(1589):704 - 716. Available from: http://rstb.royalsocietypublishing.org/content/367/1589/704.abstract?sid=18017e4e-a297-426c-b5e8-269f9a2f7cde
Full text available at http://rstb.royalsocietypublishing.org/content/367/1589/704.abstract?sid...
The olfactory bulb is in the oldest part of our brain. It connects directly to the amygdala (our ‘emotion center’) and our prefrontal cortex, giving smells a more direct pathway to memory than our other senses. But the olfactory bulb is only part of the system processing smells. It projects to several other regions, all of which are together called the primary olfactory cortex, and of which the most prominent member is the piriform cortex. More recently, however, it has been suggested that it would be more useful to regard the olfactory bulb as the primary olfactory cortex (primary in the sense that it is first), while the piriform cortex should be regarded as association cortex — meaning that it integrates sensory information with ‘higher-order’ (cognitive, contextual, and behavioral) information.
Testing this hypothesis, a new rat study has found that, when rats were given training to distinguish various odors, each smell produced a different pattern of electrical activity in the olfactory bulb. However, only those smells that the rat could distinguish from others were reflected in distinct patterns of brain activity in the anterior piriform cortex, while smells that the rat couldn’t differentiate produced identical brain activity patterns there. Interestingly, the smells that the rats could easily distinguish were ones in which one of the ten components in the target odor had been replaced with a new component. The smells they found difficult to distinguish were those in which a component had simply been deleted.
When a new group of rats was given additional training (8 days vs the 2 days given the original group), they eventually learned to discriminate between the odors the first animals couldn’t distinguish, and this was reflected in distinct patterns of brain activity in the anterior piriform cortex. When a third group were taught to ignore the difference between odors the first rats could readily distinguish, they became unable to tell the odors apart, and similar patterns of brain activity were produced in the piriform cortex.
The effects of training were also quite stable — they were still evident after two weeks.
These findings support the idea of the piriform cortex as association cortex. It is here that experience modified neuronal activity. In the olfactory bulb, where all the various odors were reflected in different patterns of activity right from the beginning (meaning that this part of the brain could discriminate between odors that the rat itself couldn’t distinguish), training made no difference to the patterns of activity.
Having said that, it should be noted that this is not entirely consistent with previous research. Several studies have found that odor training produces changes in the representations in the olfactory bulb. The difference may lie in the method of neural recording.
How far does this generalize to the human brain? Human studies have suggested that odors are represented in the posterior piriform cortex rather than the anterior piriform cortex. They have also suggested that the anterior piriform cortex is involved in expectations relating to the smells, rather than representing the smells themselves. Whether these differences reflect species differences, task differences, or methodological differences, remains to be seen.
But whether or not the same exact regions are involved, there are practical implications we can consider. The findings do suggest that one road to olfactory impairment is through neglect — if you learn to ignore differences between smells, you will become increasingly less able to do so. An impaired sense of smell has been found in Alzheimer’s disease, Parkinson's disease, schizophrenia, and even normal aging. While some of that may well reflect impairment earlier in the perception process, some of it may reflect the consequences of neglect. The burning question is, then, would it be possible to restore smell function through odor training?
I’d really like to see this study replicated with old rats.
 . Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity. Nat Neurosci [Internet]. 2011 ;advance online publication. Available from: http://dx.doi.org/10.1038/nn.2966
Math-anxiety can greatly lower performance on math problems, but just because you suffer from math-anxiety doesn’t mean you’re necessarily going to perform badly. A study involving 28 college students has found that some of the students anxious about math performed better than other math-anxious students, and such performance differences were associated with differences in brain activity.
Math-anxious students who performed well showed increased activity in fronto-parietal regions of the brain prior to doing math problems — that is, in preparation for it. Those students who activated these regions got an average 83% of the problems correct, compared to 88% for students with low math anxiety, and 68% for math-anxious students who didn’t activate these regions. (Students with low anxiety didn’t activate them either.)
The fronto-parietal regions activated included the inferior frontal junction, inferior parietal lobule, and left anterior inferior frontal gyrus — regions involved in cognitive control and reappraisal of negative emotional responses (e.g. task-shifting and inhibiting inappropriate responses). Such anticipatory activity in the fronto-parietal region correlated with activity in the dorsomedial caudate, nucleus accumbens, and left hippocampus during math activity. These sub-cortical regions (regions deep within the brain, beneath the cortex) are important for coordinating task demands and motivational factors during the execution of a task. In particular, the dorsomedial caudate and hippocampus are highly interconnected and thought to form a circuit important for flexible, on-line processing. In contrast, performance was not affected by activity in ‘emotional’ regions, such as the amygdala, insula, and hypothalamus.
In other words, what’s important is not your level of anxiety, but your ability to prepare yourself for it, and control your responses. What this suggests is that the best way of dealing with math anxiety is to learn how to control negative emotional responses to math, rather than trying to get rid of them.
Given that cognitive control and emotional regulation are slow to mature, it also suggests that these effects are greater among younger students.
The findings are consistent with a theory that anxiety hinders cognitive performance by limiting the ability to shift attention and inhibit irrelevant/distracting information.
Note that students in the two groups (high and low anxiety) did not differ in working memory capacity or in general levels of anxiety.
 . Mathematics Anxiety: Separating the Math from the Anxiety. Cerebral Cortex [Internet]. 2011 . Available from: http://cercor.oxfordjournals.org/content/early/2011/10/19/cercor.bhr289.abstract
You can download a copy of the study here: Math anxiety.pdf
Following on from research showing that long-term meditation is associated with gray matter increases across the brain, an imaging study involving 27 long-term meditators (average age 52) and 27 controls (matched by age and sex) has revealed pronounced differences in white-matter connectivity between their brains.
The differences reflect white-matter tracts in the meditators’ brains being more numerous, more dense, more myelinated, or more coherent in orientation (unfortunately the technology does not yet allow us to disentangle these) — thus, better able to quickly relay electrical signals.
While the differences were evident among major pathways throughout the brain, the greatest differences were seen within the temporal part of the superior longitudinal fasciculus (bundles of neurons connecting the front and the back of the cerebrum) in the left hemisphere; the corticospinal tract (a collection of axons that travel between the cerebral cortex of the brain and the spinal cord), and the uncinate fasciculus (connecting parts of the limbic system, such as the hippocampus and amygdala, with the frontal cortex) in both hemispheres.
These findings are consistent with the regions in which gray matter increases have been found. For example, the tSLF connects with the caudal area of the temporal lobe, the inferior temporal gyrus, and the superior temporal gyrus; the UNC connects the orbitofrontal cortex with the amygdala and hippocampal gyrus
It’s possible, of course, that those who are drawn to meditation, or who are likely to engage in it long term, have fundamentally different brains from other people. However, it is more likely (and more consistent with research showing the short-term effects of meditation) that the practice of meditation changes the brain.
The precise mechanism whereby meditation might have these effects can only be speculated. However, more broadly, we can say that meditation might induce physical changes in the brain, or it might be protecting against age-related reduction. Most likely of all, perhaps, both processes might be going on, perhaps in different regions or networks.
Regardless of the mechanism, the evidence that meditation has cognitive benefits is steadily accumulating.
The number of years the meditators had practiced ranged from 5 to 46. They reported a number of different meditation styles, including Shamatha, Vipassana and Zazen.
 . Enhanced brain connectivity in long-term meditation practitioners. NeuroImage [Internet]. 2011 ;57(4):1308 - 1316. Available from: http://www.sciencedirect.com/science/article/pii/S1053811911006008
Most memory research has concerned itself with learning over time, but many memories, of course, become fixed in our mind after only one experience. The mechanism by which we acquire knowledge from single events is not well understood, but a new study sheds some light on it.
The study involved participants being presented with images degraded almost beyond recognition. After a few moments, the original image was revealed, generating an “aha!” type moment. Insight is an experience that is frequently remembered well after a single occurrence. Participants repeated the exercise with dozens of different images.
Memory for these images was tested a week later, when participants were again shown the degraded images, and asked to recall details of the actual image.
Around half the images were remembered. But what’s intriguing is that the initial learning experience took place in a brain scanner, and to the researchers’ surprise, one of the highly active areas during the moment of insight was the amygdala. Moreover, high activity in the amygdala predicted that those images would be remembered a week later.
It seems the more we learn about the amygdala, the further its involvement extends. In this case, it’s suggested that the amygdala signals to other parts of the brain that an event is significant. In other words, it gives a value judgment, decreeing whether an event is worthy of being remembered. Presumably the greater the value, the more effort the brain puts into consolidating the information.
It is not thought, from the images used, that those associated with high activity in the amygdala were more ‘emotional’ than the other images.
 . Uncovering Camouflage: Amygdala Activation Predicts Long-Term Memory of Induced Perceptual Insight. Neuron [Internet]. 2011 ;69(5):1002 - 1014. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0896627311001115
Brain images of 16 participants in an 8-week mindfulness meditation program, taken two weeks before and after the program, have found measurable changes in brain regions associated with memory, sense of self, empathy and stress. Specifically, they showed increased grey-matter density in the left hippocampus, posterior cingulate cortex, temporo-parietal junction, and cerebellum, as well as decreased grey-matter density in the amygdala. Similar brain scans of a control group of non-meditators (those on a waiting list for the program) showed no such changes over time.
Although a number of studies have found differences in the brains of experienced meditators and those who don’t practice meditation, this is the first to demonstrate that those differences are actually produced by meditation.
The Mindfulness-Based Stress Reduction program involved weekly meetings that included practice of mindfulness meditation and audio recordings for guided meditation practice. Participants reported spending an average of 27 minutes each day practicing mindfulness exercises.
 . Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Research: Neuroimaging [Internet]. 2011 ;191(1):36 - 43. Available from: http://www.sciencedirect.com/science/article/B6TBW-51F813Y-2/2/9b58b2e4bf3dc7a5422e04248ad51fb8
Last month I reported on a finding that toddlers with autism spectrum disorder showed a strong preference for looking at moving shapes rather than active people. This lower interest in people is supported by a new imaging study involving 62 children aged 4-17, of whom 25 were diagnosed with autistic spectrum disorder and 20 were siblings of children with ASD.
In the study, participants were shown point-light displays (videos created by placing lights on the major joints of a person and filming them moving in the dark). Those with ASD showed reduced activity in specific regions (right amygdala, ventromedial prefrontal cortex, right posterior superior temporal sulcus, left ventrolateral prefrontal cortex, and the fusiform gyri) when they were watching a point-light display of biological motion compared with a display of moving dots. These same regions have also been implicated in previous research with adults with ASD.
Moreover, the severity of social deficits correlated with degrees of activity in the right pSTS specifically. More surprisingly, other brain regions (left dorsolateral prefrontal cortex, right inferior temporal gyrus, and a different part of the fusiform gyri) showed reduced activity in both the siblings group and the ASD group compared to controls. The sibling group also showed signs of compensatory activity, with some regions (right posterior temporal sulcus and a different part of the ventromedial prefrontal cortex) working harder than normal.
The implications of this will be somewhat controversial, and more research will be needed to verify these findings.
 Neural signatures of autism. Proceedings of the National Academy of Sciences [Internet]. 2010 . Available from: http://www.pnas.org/content/early/2010/11/05/1010412107.abstract?sid=b9b6576f-6507-4e67-b6b2-df151de07647
Full text available at http://www.pnas.org/content/early/2010/11/05/1010412107.full.pdf+html
A rat study using powerful imaging techniques has revealed how an injured brain continues to change long after the original trauma. Widespread decreases in brain functioning over a period of months were seen in specific brain regions, in particular the hippocampus, amygdala, and ipsilateral cortex, even when these were remote from the site of direct trauma and unaccompanied by signs of injury.
The findings indicate that there is a time window during which intervention could reduce these processes and protect against some of the disabling consequences of TBI.
 Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat. J Nucl Med [Internet]. 2010 ;51(11):1788 - 1795. Available from: http://jnm.snmjournals.org/cgi/content/abstract/51/11/1788
The issue of “mommy brain” is a complex one. Inconsistent research results make it clear that there is no simple answer to the question of whether or not pregnancy and infant care change women’s brains. But a new study adds to the picture.
Brain scans of 19 women two to four weeks and three to four months after they gave birth showed that grey matter volume increased by a small but significant amount in the midbrain (amygdala, substantia nigra, hypothalamus), prefrontal cortex, and parietal lobe. These areas are involved in motivation and reward, emotion regulation, planning, and sensory perception.
Mothers who were most enthusiastic about their babies were significantly more likely to show this increase in the midbrain regions. The authors speculated that the “maternal instinct” might be less of an instinctive response and more of a result of active brain building. Interestingly, while the brain’s reward regions don’t usually change as a result of learning, one experience that does have this effect is that of addiction.
While the reasons may have to do with genes, personality traits, infant behavior, or present circumstances, previous research has found that mothers who had more nurturing in their childhood had more grey matter in those brain regions involved in empathy and reading faces, which also correlated with the degree of activation in those regions when their baby cried.
A larger study is of course needed to confirm these findings.
 . The plasticity of human maternal brain: Longitudinal changes in brain anatomy during the early postpartum period. Behavioral Neuroscience [Internet]. 2010 ;124(5):695 - 700. Available from: http://psycnet.apa.org/journals/bne/124/5/695/
A number of studies in recent years have revealed the amazing ability of the human brain to compensate for damage down to its part. In the latest of these, it’s been found that loss of the amygdala doesn’t have to mean that new memories will be void of emotion. Instead, it appears, a region called the bed nuclei can step in to take its place. The bed nuclei are slower to process information than the amygdala, and in normal circumstances are inhibited by the amygdala. The study looked specifically at fear conditioning, for which the amygdala has been considered crucial.
The finding offers the hope that therapies to promote compensatory shifts in function might help those who have suffered damage to parts of their brain.
 . Compensation in the neural circuitry of fear conditioning awakens learning circuits in the bed nuclei of the stria terminalis. Proceedings of the National Academy of Sciences [Internet]. 2010 ;107(33):14881 - 14886. Available from: http://www.pnas.org/content/107/33/14881.abstract
A rat study shows how Ritalin improves concentration and, it now appears, speed of learning. The study reveals that it does this by increasing the activity of dopamine at two specific types of neurotransmitter receptors in the amygdala. The dopamine receptor tagged “D2” appears to control the ability to stay focused on a task, while the D1 receptor underlies learning efficiency. The finding may help the development of better-targeted drugs.
 . Methylphenidate facilitates learning-induced amygdala plasticity. Nat Neurosci [Internet]. 2010 ;13(4):475 - 481. Available from: http://dx.doi.org/10.1038/nn.2506
An imaging study reveals why older adults are better at remembering positive events. The study, involving young adults (ages 19-31) and older adults (ages 61-80) being shown a series of photographs with positive and negative themes, found that while there was no difference in brain activity patterns between the age groups for the negative photos, there were age differences for the positive photos. In older adult brains, but not the younger, two emotion-processing regions (the ventromedial prefrontal cortex and the amygdala) strongly influenced the memory-encoding hippocampus.
 . There are age-related changes in neural connectivity during the encoding of positive, but not negative, information. Cortex [Internet]. 2010 ;46(4):425 - 433. Available from: http://www.cortexjournal.net/article/S0010-9452(09)00152-X/abstract
Older news items (pre-2010) brought over from the old website
Alcoholics show abnormal brain activity when processing facial expressions
Excessive chronic drinking is known to be associated with deficits in comprehending emotional information, such as recognizing different facial expressions. Now an imaging study of abstinent long-term alcoholics has found that they show decreased and abnormal activity in the amygdala and hippocampus when looking at facial expressions. They also show increased activity in the lateral prefrontal cortex, perhaps in an attempt to compensate for the failure of the limbic areas. The finding is consistent with other studies showing alcoholics invoking additional and sometimes higher-order brain systems to accomplish a relatively simple task at normal levels. The study compared 15 abstinent long-term alcoholics and 15 healthy, nonalcoholic controls, matched on socioeconomic backgrounds, age, education, and IQ.
Marinkovic, K. et al. 2009. Alcoholism and Dampened Temporal Limbic Activation to Emotional Faces. Alcoholism: Clinical and Experimental Research, Published Online: Aug 10 2009
Measuring brain atrophy in patients with mild cognitive impairment
A study involving 269 patients with mild cognitive impairment provides evidence that a fully automated procedure called Volumetric MRI (that can be done in a clinical setting) can accurately and quickly measure parts of the medial temporal lobe and compare them to expected size. It also found that not only atrophy in the hippocampus but also the amygdala is associated with a greater risk of conversion to Alzheimer’s.
Kovacevic, S. et al. 2009. High-throughput, Fully Automated Volumetry for Prediction of MMSE and CDR Decline in Mild Cognitive Impairment. Alzheimer Disease & Associated Disorders, 23 (2), 139-145.
Aging brains allow negative memories to fade
Another study has found that older adults (average age 70) remember fewer negative images than younger adults (average age 24), and that this has to do with differences in brain activity. When shown negative images, the older participants had reduced interactions between the amygdala and the hippocampus, and increased interactions between the amygdala and the dorsolateral prefrontal cortex. It seems that the older participants were using thinking rather than feeling processes to store these emotional memories, sacrificing information for emotional stability. The findings are consistent with earlier research showing that healthy seniors are able to regulate emotion better than younger people.
St. Jacques, P.L., Dolcos, F. & Cabeza, R. 2009. Effects of Aging on Functional Connectivity of the Amygdala for Subsequent Memory of Negative Pictures: A Network Analysis of Functional Magnetic Resonance Imaging Data. Psychological Science, 20 (1), 74-84.
Long-term cannabis users may have structural brain abnormalities
An imaging study of 15 men who smoked more than five cannabis joints daily for more than 10 years has found that, compared with individuals who were not cannabis users, the heavy cannabis users tended to have a smaller hippocampus and amygdala. They also performed significantly worse on verbal learning, but this didn’t correlate with regional brain volumes.
Yücel, M. et al. 2008. Regional Brain Abnormalities Associated With Long-term Heavy Cannabis Use . Archives of General Psychiatry, 65(6), 694-701.
Some brain injuries may reduce the likelihood of PTSD
A study of combat-exposed Vietnam War veterans shows that those who suffered injuries to the amygdala or the ventromedial prefrontal cortex were less likely to develop post-traumatic stress disorder than those who suffered damage in other areas or had no head injuries (in fact none of those whose amygdala was damaged developed PTSD). The findings suggest that treatment designed to inhibit the activity of these two areas might provide relief from PTSD.
Koenigs, M. et al. 2007. Focal Brain Damage Protects Against Post-Traumatic Stress Disorder in Combat Veterans. Nature Neuroscience, published on-line December 23
Anticipation strengthens memory
An imaging study has revealed that the amygdala and the hippocampus become activated when a person is anticipating a difficult situation (some type of gruesome picture). Moreover, the higher the level of activation during this anticipation, the better the pictures were remembered two weeks later. The study demonstrates how expectancy can affect long-term memory formation, and suggests that the greater our anxiety about a situation, the better we’ll remember that situation. If it’s an unpleasant one, this will only reinforce the anxiety, setting up a vicious cycle. The study has important implications for the treatment of psychological conditions such as post-traumatic stress disorder and social anxiety.
Mackiewicz, K.L., Sarinopoulos, I., Cleven, K.L. & Nitschke, J.B. 2006. The effect of anticipation and the specificity of sex differences for amygdala and hippocampus function in emotional memory. PNAS, 103, 14200-14205.
How emotions interfere with memory
We know emotion can interfere with cognitive processes. Now an imaging study adds to our understanding of how that occurs. Emotional images evoked strong activity in typical emotional processing regions (amygdala and ventrolateral prefrontal cortex) while simultaneously deactivating regions involved in memory processing (dorsolateral prefrontal cortex and lateral parietal cortex). The researchers also found individual differences among the subjects in their response to the images. People who showed greater activity in a brain region associated with the inhibition of response to emotional stimuli rated the emotional distracters as less distracting.
Dolcos, F. & McCarthy, G. 2006. Brain Systems Mediating Cognitive Interference by Emotional Distraction. Journal of Neuroscience, 26, 2072-2079.
A single memory is processed in three separate parts of the brain
A rat study has demonstrated that a single experience is indeed processed differently in separate parts of the brain. They found that when the rats were confined in a dark compartment of a familiar box and given a mild shock, the hippocampus was involved in processing memory for context, while the anterior cingulate cortex was responsible for retaining memories involving unpleasant stimuli, and the amygdala consolidated memories more broadly and influenced the storage of both contextual and unpleasant information.
Malin, E.L. & McGaugh, J.L. 2006. Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock. Proceedings of the National Academy of Sciences, 103 (6), 1959-1963.
Memory of fear more complex than supposed
It seems that fear memory is more complex than has been thought. A new mouse study has shown that not only the hippocampus and amygdala are involved, but that the prefrontal cortex is also critical. The development of the fear association doesn’t occur immediately after a distressing event, but develops over time. The process, it now seems, depends directly on a protein called NR2B.
How trauma triggers long-lasting memories in the brain
A rat study sheds more light on why emotional experiences tend to be better remembered than emotionally neutral events. The study found that emotionally arousing events activated the amygdala, which then increased a specific protein — activity-regulated cytoskeletal protein ("Arc") — in the neurons in the hippocampus. It's thought that Arc helps store these memories by strengthening the synapses.
McIntyre, C.K., Miyashita, T., Setlow, B., Marjon, K.D., Steward, O., Guzowski, J.F. & McGaugh, J.L. 2005. Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proceedings of the National Academy of Sciences, 102 (30), 10718-10723.
Why traumatic memories have the power they do
In the first imaging study to look at retrieval of emotional memories after a long period (one year after encoding), researchers found that people did recall emotional images, both pleasant and unpleasant, better than emotionally-neutral images. This recall was associated with higher activity in both the amygdala and the hippocampus. The synchronicity of activity between these two regions suggested that each region triggers the other, creating a self-reinforcing "memory loop" in which an emotional cue might trigger recall of the event, which then loops back to a re-experiencing of the emotion of the event. The findings suggest why people subject to traumatic events may be trapped in a cycle of emotion and recall that aggravates post-traumatic stress disorder, and may also suggest why therapies in which people relive such memories and reshape perspective to make it less traumatic can help people cope with such memories.
Dolcos, F., LaBar, K.S. & Cabeza, R. 2005. Remembering one year later: Role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories. PNAS, 102 (7), 2626-2631.
Different brain regions for arousing and non-arousing words
An imaging study has found that words representing arousing events (e.g., “rape”, “slaughter”) activate cells in the amygdala, while nonarousing words (e.g., “sorrow”, “mourning”) activated cells in the prefrontal cortex. The hippocampus was active for both type of words. On average, people remembered more of the arousing words than the others, suggesting stress hormones, released as part of the response to emotionally arousing events, are responsible for enhancing memories of those events.
Kensinger, E.A. & Corkin, S. 2004. Two routes to emotional memory: Distinct neural processes for valence and arousal. PNAS, 101, 3310-3315. Published online before print February 23 2004, 10.1073/pnas.0306408101
Key brain link in associative learning directly observed
Rat studies have now shown that the amygdala supports the formation of new associations by changing nerve cell firing patterns in a different but connected part of the brain. In earlier studies, the researchers had demonstrated that nerve cells in the amygdala and the orbitofrontal cortex changed their firing patterns to reflect new associations between cues and outcomes. In this later study, they examined how changes in neural activity in amygdala might be supporting changes in the orbitofrontal cortex. Rats were first deprived of water, then repeatedly given either desirable drinking water, laced with sugar, or undesirable drinking water, laced with quinine. The associations then learned would show up in the orbitofrontal cortex when the rats smelled the odor cue. The same activation patterns did not however, show up in those rats who had their amygdala chemically lesioned (although these rats still learned to avoid the undesirable drinking water). Specifically, although lesioned rats had neurons in the orbitofrontal cortex that were responsive to the odor cues, they did not have neurons that were responsive in anticipation of the predicted outcome. The responsive neurons were also less associative, more responsive to the identity of the cue rather than the association betwen odor and consequence.
Schoenbaum, G., Setlow, B., Saddoris, M.P. & Gallagher, M. 2003. Encoding Predicted Outcome and Acquired Value in Orbitofrontal Cortex during Cue Sampling Depends upon Input from Basolateral Amygdala. Neuron, 39, 855-867.
Fear-conditioning study demonstrates long-suspected link between longterm potentiation and learning
It has long been felt that learning and memory must require physical changes in neurons that increase their responsivity to other neurons, so that they will continue to respond in the long-term even in the absence of external stimuli. Until now, however, noone has been able to actually demonstrate that this long-term potentiation occurs during learning. A new direction has proved to be more successful. Investigation of changes in the amygdala (a part of the brain associated with emotional response) after rats had been trained to fear a sound, found that postsynaptic neurons in the amygdala failed to produce any noticeable increase in electrical current, suggesting they had already been potentiated by their presynaptic partners.
Tsvetkov, E., Carlezon Jr.,W.A., Benes, F.M., Kandel, E.R. & Bolshakov, V.Y. 2002. Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala. Neuron, 34, 289-300.
Amygdala may be critical for allowing perception of emotionally significant events despite inattention
We choose what to pay attention to, what to remember. We give more weight to some things than others. Our perceptions and memories of events are influenced by our preconceptions, and by our moods. Researchers at Yale and New York University have recently published research indicating that the part of the brain known as the amygdala is responsible for the influence of emotion on perception. This builds on previous research showing that the amygdala is critically involved in computing the emotional significance of events. The amygdala is connected to those brain regions dealing with sensory experiences, and the theory that these connections allow the amygdala to influence early perceptual processing is supported by this research. Dr. Anderson suggests that “the amygdala appears to be critical for the emotional tuning of perceptual experience, allowing perception of emotionally significant events to occur despite inattention.”
Anderson, A.K. & Phelps, E.A. 2001. Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature, 411, 305-309.