More on the importance of calpain

January, 2010

A new study suggests that all the great benefits of BDNF for learning and memory are in fact due to calpain.

Last month I reported on a finding that estrogen acts through calpain, a protein crucial to learning and memory, that acts as a neurotransmitter in the brain. Now a new study has found that BDNF activates calpain, and when it does, the spine structure changes in ways similar to those that occur during learning. When activation was blocked with calpain inhibitors, the addition of BDNF had no effect. All this implies that all the great benefits of BDNF for learning and memory are in fact due to calpain.


Related News

Data from 133,479 women in the California Teachers Study has found that those who reported doing moderate physical activity (such as brisk walking) in the three years before enrolling in the study were 20% less likely to suffer a stroke than women who reported no activity.

The issue of the effect of menopause on women’s cognition, and whether hormone therapy helps older women fight cognitive decline and dementia, has been a murky one. Increasing evidence suggests that the timing and type of therapy is critical.

Being a woman of a certain age, I generally take notice of research into the effects of menopause on cognition.

It’s been unclear whether hormone therapy helps older women reduce their risk of Alzheimer’s or in fact increases the risk.

A study involving 75 perimenopausal women aged 40 to 60 has found that those with memory complaints tended to show impairments in

Obesity has been linked to cognitive decline, but a new study involving 300 post-menopausal women has found that higher BMI was associated with higher cognitive scores.

The very large and long-running Women's Health Initiative study surprised everyone when it produced its finding that hormone therapy generally increased rather than decreased stroke risk as well as other health problems.

Recent rodent studies add to our understanding of how estrogen affects learning and memory.

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health newsSubscribe to Latest news