Children with Alzheimer's gene may be more vulnerable to brain damage from smog

A small study involving 50 children and teens living in Mexico City (aged 13.4 ± 4.8 years) has found that those with the 'Alzheimer's gene' APOEε4 (22 of the 50) were more vulnerable to the effects of air pollution on cognition. Those with the gene variant had a reduced NAA/Cr ratio in the right frontal white matter (as those with Alzheimer's do), poorer attention and short-term memory, and below-average scores in Verbal and Full Scale IQ (>10 points), compared to those with the 'normal' ε3 variant. They also had problems with odor detection, also typical of those developing Alzheimer's.

The study is small and lacks a proper control group, but while other studies have found some signs of early brain differences in those carrying the ε4 variant, they have not been nearly as marked as this. The finding certainly warrants concern and further study.

http://www.eurekalert.org/pub_releases/2015-02/tuom-usf021115.php

http://www.eurekalert.org/pub_releases/2015-02/ip-dis020215.php

Reference: 

Calderón-Garcidueñas, L. et al. 2015. Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution. Journal of Alzheimer's Disease, 45(3)

Related News

Untreated sleep apnea in children shrinks brain & may slow development

Brain scans of children who have moderate or severe obstructive sleep apnea have found significant reductions of gray matter across the brain.

A study involving 30 children (aged 8-10), of whom 15 had experienced a sports-related concussion two years earlier, and all of whom were athletically active, found that those with a history of concussion performed worse on tests of

Following a previous study linking higher maternal levels of two common chemicals with slower mental and motor development in preschoolers, a new study has found that this effect continues into school age.

A gene linked to Alzheimer's has been linked to brain changes in childhood.

A study involving 362 children with reading problems has found that 16 weeks of daily 600 mg supplements of omega-3 DHA from algal sources improved their sleep. According to a sleep questionnaire filled out by parents, 40% of these children had significant sleep problems.

I recently discussed some of the implications of head injuries and how even mild concussions can have serious and long-term consequences.

In the study, 18 children (aged 7-8), 20 adolescents (13-14), and 20 young adults (20-29) were shown pictures and asked to decide whether it was a new picture or one they had seen earlier.

Brain imaging data from 103 healthy people aged 5-32, each of whom was scanned at least twice, has demonstrated that wiring to the

Childhood amnesia — our inability to remember almost everything that happened to us when very young — is always interesting. It’s not as simple as an inability to form long-term memories.

Children’s ability to remember past events improves as they get older. This has been thought by many to be due to the slow development of the

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health news