Loss of smell early sign of Alzheimer’s

A pilot study involving 94 older adults, of whom 18 had Alzheimer’s, 24 had MCI, 26 other dementias, and 26 were healthy controls, has found those with Alzheimer’s were significantly less able to detect the smell of peanut butter. Peanut butter was chosen because of its purity and accessibility (not because there's something special about its smell!).

The test was undertaken by the patient closing eyes and mouth and blocking one nostril, while the clinician held a ruler next to the open nostril and moved 14g of peanut butter in an open jar up the ruler one centimeter at a time, as the patient breathed out. Those in the early stages of Alzheimer’s disease showed a dramatic difference in detecting odor between the left and right nostril. The average distance at which the peanut butter was detected was 5.1 cm for the left nostril, compared to 17.4 cm for the right. The difference between these (12.4 cm) compares to an average 4.8 cm for other dementias, 1.9 for MCI, and 0 for healthy controls.

Of the 24 patients with MCI, only 10 patients showed a left nostril impairment, suggesting that this may be an indication of who will go on to develop Alzheimer’s.

http://www.futurity.org/can-peanut-butter-smell-test-confirm-alzheimers/

[3609] Stamps JJ, Bartoshuk LM, Heilman KM. A brief olfactory test for Alzheimer's disease. Journal of the Neurological Sciences [Internet]. 2013 ;333(1):19 - 24. Available from: http://www.jns-journal.com/article/S0022-510X(13)00311-0/abstract

Related News

A new study shows that a combination of inflammation and hypoxia activates microglia in a way that persistently weakens the connection between neurons,

A new function has been found for the

New research helps explain the role of amyloid-beta plaques in the development of Alzheimer's, by finding that the

Creating amyloid-beta requires the convergence of a protein called

A Swedish study of some 4,000 60-year-olds has found that regular “non-exercise” physical activity such as gardening or DIY significantly reduced risk of heart attack or stroke, with those who were most active on a daily basis having a 27% lower risk of a heart attack or stroke and a 30% reduced

A year-long study involving 424 sedentary, mobility-limited seniors aged 70-89, has found that variants in a specific gene (the ACE I/D gene) affect seniors’ ability to benefit from exercise.

Data from the American National Health and Nutrition Examination Survey (NHANES) III, involving 3,659 individuals (men aged 55+; women 65+), has found that the more muscle mass older adults have, the less likely they are to die prematurely.

A four-year study involving 1,502 healthy older adults (50+) has found that the frequency of negative interactions with family members (not partners or children) and friends was associated with an increased risk of developing hypertension in women (but not in men).

A study involving 74 older adults (70+), of whom 3 had mild dementia, 33 were cognitively normal and 38 had mild cognitive impairment, has found that high levels of "good" cholesterol and low levels of "bad" cholesterol correlated with lower levels of the amyloid-beta plaques in the brain (a hal

Data from 11 different cohort studies, involving more than 600,000 people from around the world, has found that:

Pages

Subscribe to Latest newsSubscribe to Latest newsSubscribe to Latest health news