gamma-secretase

is one of the two secretases implicated in plaque formation. Gamma-secretase makes the final cut in the APP, and it does so within the cell membrane, using the thickness of the membrane as a guide for where to cut. Membranes expand or contract depending on the lipid content of the cell, and so, therefore, does the length of the cut product. When the cleavage goes wrong, plaques result. Gamma-secretase is divided into several subunits, which have recently been discovered to act separately on different tissues (see CD147).

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